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Catalog Number Size Price
LS-B16371-50 50 µl (1 mg/ml) $460 
TH / Tyrosine Hydroxylase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
TH / Tyrosine Hydroxylase Antibody - Immunofluorescent staining of HeLa cells using anti-TH mouse monoclonal antibody.
TH / Tyrosine Hydroxylase Antibody - Anti-TH mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TH.
TH / Tyrosine Hydroxylase Antibody - Western blot of extracts (35ug) from 9 different cell lines by using anti-TH monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
TH / Tyrosine Hydroxylase Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TH (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TH.
TH / Tyrosine Hydroxylase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
TH / Tyrosine Hydroxylase Antibody - Immunofluorescent staining of HeLa cells using anti-TH mouse monoclonal antibody.
TH / Tyrosine Hydroxylase Antibody - Anti-TH mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TH.
TH / Tyrosine Hydroxylase Antibody - Western blot of extracts (35ug) from 9 different cell lines by using anti-TH monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
TH / Tyrosine Hydroxylase Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TH (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TH.
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PathPlus™ Monoclonal Mouse anti‑Human TH / Tyrosine Hydroxylase Antibody (clone OTI3H3, IHC, IF, WB) LS‑B16371

PathPlus™ Monoclonal Mouse anti‑Human TH / Tyrosine Hydroxylase Antibody (clone OTI3H3, IHC, IF, WB) LS‑B16371

Note: This antibody replaces LS-C338121
Antibody:
TH / Tyrosine Hydroxylase Mouse anti-Human Monoclonal (OTI3H3) Antibody
Application:
IHC-P, IF, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-B16371-50
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
TH / Tyrosine Hydroxylase Mouse anti-Human Monoclonal (OTI3H3) Antibody
Application:
IHC-P, IF, WB
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified

Specifications

Description
TH (tyrosine hydroxylase) is an enzyme that converts L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), a dopamine precursor. It is the rate-limiting enzyme in the synthesis of catecholamines and plays a key role in the physiology of adrenergic neurons. TH is encoded by four distinct mRNAs produced by alternative splicing of a single primary transcript, and expression of the mRNAs varies in different parts of the nervous system. Mutations in TH are the cause of autosomal recessive Segawa syndrome and are thought to be involved in Parkinson’s disease and schizophrenia. TH deficiency leads to dopa-nonresponsive dystonia and progressive encephalopathy via an impaired ability to synthesize epinephrine, norepinephrine and dopamine. In immunohistochemistry of normal tissue, TH has cytoplasmic positivity in the adrenal medulla, in peripheral sympathetic nerve fibers, and in the caudate nucleus in the brain. References: Nature Structural Biology. 1997. 4 (7): 578–85, PMID 9228951; CNS Neurol Disord Drug Targets. 2012 Jun 1;11(4):395-409, PMID: 22483313; Arch Biochem Biophys. 2011 Apr 1;508(1):1-12, PMID: 21176768; Ann Neurol. 2003;54 Suppl 6:S56-65, PMID: 12891655
Target
Human TH / Tyrosine Hydroxylase
Synonyms
TH | DYT14 | Dystonia 14 | TYH | Tyrosine 3-hydroxylase | Tyrosine hydroxylase | DYT5b | Tyrosine 3-monooxygenase
Host
Mouse
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Clone
OTI3H3
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Full length human recombinant protein of human TH(NP_000351) produced in HEK293T cell.
Specificity
Human TH / Tyrosine Hydroxylase
Applications
  • IHC - Paraffin (10 µg/ml)
  • Immunofluorescence (1:100)
  • Western blot (1:400 - 1:4000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, pH 7.3, 0.02% Sodium Azide, 50% Glycerol, 1% BSA
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About TH / Tyrosine Hydroxylase
P07101 NM_000360 NP_000351.2

Validation

TH / Tyrosine Hydroxylase Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ TH / Tyrosine Hydroxylase Antibody (clone OTI3H3) for IHC, IF/Immunofluorescence, WB/Western LS-B16371 has an LSBio Rating of
Laboratory Validation Score (5)

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 2/29/2024