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| Catalog Number | Size | Price |
|---|---|---|
| LS-B16130-100 | 100 µl (1 mg/ml) | $460 |
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2 of 2
PathPlus™ Monoclonal Mouse anti‑Human CR1 / CD35 Antibody (IHC) LS‑B16130
PathPlus™ Monoclonal Mouse anti‑Human CR1 / CD35 Antibody (IHC) LS‑B16130
Note: This antibody replaces LS-C744467
Antibody:
CR1 / CD35 Mouse anti-Human Monoclonal Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
CR1 / CD35 Mouse anti-Human Monoclonal Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
CD35 (also known as complement receptor type 1, CR1 or complement C3b/C4b receptor) is a membrane-bound protein member of the regulators of complement activation family. It mediates the immune adherence phenomenon; cellular binding to particles/immune complexes with activated complement. It also mediates inhibitory signals in B lymphocytes. CD35 is expressed at the cell surface in erythrocytes, dendritic cells, leukocytes, and podocytes. Polymorphisms and mutations of the CD35 gene have been reported in systemic lupus erythematosus, mesangiocapillary glomerulonephritis, gallbladder carcinoma, and sarcoidosis. Staining is used to identify dendritic cells and follicular dendritic cell tumors.
References: Immunol Res. 1987;6(3):192-209. PMID: 2960763; Proc R Soc Med. 1956;49(1):55-58. PMID: 13289834; J Immunol. 2002;168(6):2782-2788. PMID: 11884446; Mol Immunol. 2009;46(14)2767-2773. doi: 10.1016/j.molimm.2009.05.181; Hum Genet. 2005;118(2):225-234. doi: 10.1007/s00439-005-0044-6; Nephron. 1986;43(4):307. doi: 10.1159/000183861; Am J Surg Pathol. 1996;20(8):944-955. PMID: 8712294.
Target
Human CR1 / CD35
Synonyms
CR1 | C3b/C4b receptor | C3-binding protein | CD35 | C3BR | Knops blood group antigen | C4BR | CD35 antigen | Complement receptor type 1 | KN
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
IgG
Monoclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Immunogen
Synthetic CD35
Applications
- IHC (1:200 - 1:400)
- IHC - Paraffin (1:25)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Use Heat-induced epitope retrieval (HIER) Citrate buffer of pH 6.0 Recommended IHC controls tissues are Tonsil. Resulting localization is Membranous
Presentation
0.5% BSA, 0.1% Kathon, Tris-Buffered Saline, DI H2O and 50% glycerol
Storage
Store at -20°C for up to 1 year.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CR1 / CD35
Validation
Human Kidney, Podocytes: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Kidney, Podocytes: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ CR1 / CD35 Antibody for IHC LS-B16130 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot, Flow Cytometry
Species:
Human
Applications:
IHC - Paraffin, Immunofluorescence, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry, ELISA
Species:
Human, Baboon, Monkey, Cynomolgus
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot, Flow Cytometry
Species:
Human
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/27/2024
Date Requested: 4/27/2024
