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Catalog Number Size Price
LS-B5508-0.05 0.05 mg $460 
CD44 Antibody - Anti-CD44 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
CD44 Antibody - Surface staining of murine splenocytes with anti-CD44 (IM7) purified / DAR-APC.
CD44 Antibody - Western blotting analysis of CD44 in HeLa cells (positive; lane 2) and MOLT-4 cells (negative; lane 1) using anti-CD44 (IM7) purified; non-reducing conditions.
CD44 Antibody - Anti-CD44 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
CD44 Antibody - Surface staining of murine splenocytes with anti-CD44 (IM7) purified / DAR-APC.
CD44 Antibody - Western blotting analysis of CD44 in HeLa cells (positive; lane 2) and MOLT-4 cells (negative; lane 1) using anti-CD44 (IM7) purified; non-reducing conditions.
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PathPlus™ Monoclonal Rat anti‑Mouse CD44 Antibody (clone IM7, IHC, WB) LS‑B5508

PathPlus™ Monoclonal Rat anti‑Mouse CD44 Antibody (clone IM7, IHC, WB) LS‑B5508

Note: This antibody replaces LS-C112460, LS-C121539, LS-C106691, LS-B11907
Antibody:
CD44 Rat anti-Mouse Monoclonal (IM7) Antibody
Application:
IHC, IHC-P, IHC-Fr, ICC, WB, IP, Flo
Reactivity:
Mouse, Human, Canine, Equine, Feline
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-B5508-0.05
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
CD44 Rat anti-Mouse Monoclonal (IM7) Antibody
Application:
IHC, IHC-P, IHC-Fr, ICC, WB, IP, Flo
Reactivity:
Mouse, Human, Canine, Equine, Feline
Format:
Unconjugated, Unmodified

Specifications

Description
CD44 is a glycoprotein receptor that is involved in cell adhesion, cell migration, and other cell-cell interactions. It plays a role in many cellular functions including lymphocyte activation, recirculation, and homing, hematopoiesis, and the progression and metastasis of cancer cells. CD44 exists in several isoforms, and the main isoform is expressed ubiquitously in the cytoplasm and membrane of various cell types throughout the body in normal and diseased tissues including cancers and autoimmune diseases. The absence of the main isoform, or the presence of certain other isoforms in cancer cells, is associated with poor prognosis. In immunohistochemistry, CD44 is a marker for squamous epithelium, and in cancer it can distinguish reactive urothelium from carcinoma in situ. It is positive in colorectal cancer, glioma, oligodendroglioma, prostatic small cell carcinoma, squamous cell and adneosquamous carcinoma. Loss of CD44 is a general marker of poor prognosis in cancer. References: Front Cell Dev Biol. 2017;5:18. doi: 10.3389/fcell.2017.00018; Saudi Med J. 2015;36(3):273-279. doi: 10.15537/smj.2015.3.9622; Arch Immunol Ther Exp (Warsz). 2004;52(1):13-26. PMID: 15053229; Pathol Int. 2012;62(7):463-470. doi: 10.1111/j.1440-1827.2012.02823.x; Recent Pat Inflamm Allergy Drug Discov. 2017;11(2):77-91. doi: 10.2174/1872213X11666170907111858; Stem Cells Transl Med. 2015;4(9):1033-1043. doi: 10.5966/sctm.2015-0048.
Target
Mouse CD44
Synonyms
CD44 | CDW44 | CD44 antigen | Cell surface glycoprotein CD44 | CSPG8 | ECMR-III | Epican | HUTCH-I | LHR | MDU2 | MC56 | MIC4 | Hermes antigen | Hyaluronate receptor | Phagocytic glycoprotein 1 | PGP-1 | PGP-I | Pgp1 | Phagocytic glycoprotein I | MDU3 | CD44R | HCELL | Heparan sulfate proteoglycan
Host
Rat
Reactivity
Mouse, Human, Canine, Equine, Feline (tested or 100% immunogen sequence identity)
Clonality
IgG2b Monoclonal
Clone
IM7
Conjugations
Unconjugated
Purification
Purified by protein-A affinity chromatography. Greater than 95% by SDS-PAGE.
Modifications
Unmodified
Immunogen
Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1.
Specificity
The rat monoclonal antibody IM7 reacts with CD44 antigen (Phagocyte glycoprotein 1), an 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes. The antibody reacts with all isoforms of mouse CD44.
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen
  • ICC
  • Western blot
  • Immunoprecipitation
  • Flow Cytometry
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, pH 7.4, 15 mM Sodium Azide
Storage
Store at 2°C to 8°C. Do not freeze.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CD44
P16070 NM_000610 NP_000601.3

Validation

CD44 Antibody - Anti-CD44 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CD44 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-CD44 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

LSBio Ratings

PathPlus™ CD44 Antibody (clone IM7) for IHC, ICC, WB/Western, IP, Flow LS-B5508 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510.

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 2/28/2024