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Catalog Number Size Price
LS-B16266-100 100 µg (200 µg/ml) $525 
CD44 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - SDS-PAGE Analysis Purified CD44 Rabbit Recombinant Monoclonal Antibody (HCAM/2875R). Confirmation of Purity and Integrity of Antibody.
CD44 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
CD44 Antibody - SDS-PAGE Analysis Purified CD44 Rabbit Recombinant Monoclonal Antibody (HCAM/2875R). Confirmation of Purity and Integrity of Antibody.
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PathPlus™ Recombinant Monoclonal Rabbit anti‑Human CD44 Antibody (clone HCAM/2875R, IHC) LS‑B16266

PathPlus™ Recombinant Monoclonal Rabbit anti‑Human CD44 Antibody (clone HCAM/2875R, IHC) LS‑B16266

Note: This antibody replaces LS-C751474
Antibody:
CD44 Rabbit anti-Human Recombinant Monoclonal (HCAM/2875R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$525
LS-B16266-100
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
CD44 Rabbit anti-Human Recombinant Monoclonal (HCAM/2875R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CD44 is a glycoprotein receptor that is involved in cell adhesion, cell migration, and other cell-cell interactions. It plays a role in many cellular functions including lymphocyte activation, recirculation, and homing, hematopoiesis, and the progression and metastasis of cancer cells. CD44 exists in several isoforms, and the main isoform is expressed ubiquitously in the cytoplasm and membrane of various cell types throughout the body in normal and diseased tissues including cancers and autoimmune diseases. The absence of the main isoform, or the presence of certain other isoforms in cancer cells, is associated with poor prognosis. In immunohistochemistry, CD44 is a marker for squamous epithelium, and in cancer it can distinguish reactive urothelium from carcinoma in situ. It is positive in colorectal cancer, glioma, oligodendroglioma, prostatic small cell carcinoma, squamous cell and adneosquamous carcinoma. Loss of CD44 is a general marker of poor prognosis in cancer. References: Front Cell Dev Biol. 2017;5:18. doi: 10.3389/fcell.2017.00018; Saudi Med J. 2015;36(3):273-279. doi: 10.15537/smj.2015.3.9622; Arch Immunol Ther Exp (Warsz). 2004;52(1):13-26. PMID: 15053229; Pathol Int. 2012;62(7):463-470. doi: 10.1111/j.1440-1827.2012.02823.x; Recent Pat Inflamm Allergy Drug Discov. 2017;11(2):77-91. doi: 10.2174/1872213X11666170907111858; Stem Cells Transl Med. 2015;4(9):1033-1043. doi: 10.5966/sctm.2015-0048.
Target
Human CD44
Synonyms
CD44 | CDW44 | CD44 antigen | Cell surface glycoprotein CD44 | CSPG8 | ECMR-III | Epican | HUTCH-I | LHR | MDU2 | MC56 | MIC4 | Hermes antigen | Hyaluronate receptor | Phagocytic glycoprotein 1 | PGP-1 | PGP-I | Pgp1 | Phagocytic glycoprotein I | MDU3 | CD44R | HCELL | Heparan sulfate proteoglycan
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Recombinant Monoclonal
Clone
HCAM/2875R
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified. Also available Azide-free, Carrier-free.
Immunogen
Stimulated human leukocytes. Antigen Molecular Weight: 80-95 kDa
Specificity
Recognizes a cell surface glycoprotein of 80-95 kDa (CD44) on lymphocytes, monocytes, and granulocytes (Leucocyte Typing Workshop V). Its epitope is resistant to digestion by trypsin and chymotrypsin. This MAb selectively interferes with lymphocyte binding to lymph node, mucosal and synovial endothelium. The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95 kDa or hematopoietic variant (CD44s). Higher molecular weight isoforms are described in epithelial cells (CD44v), which are believed to function in intercellular adhesion and stromal binding. CD44 immunostaining is commonly used for the discrimination of urothelial transitional cell carcinoma in-situ from non-neoplastic changes in the urothelium.
Applications
  • IHC - Paraffin (1:100)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistology (Formalin-fixed - 0.25-0.5 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CD44
P16070 NM_000610 NP_000601.3

Validation

CD44 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD44 Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD44 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CD44 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ CD44 Antibody (clone HCAM/2875R) for IHC LS-B16266 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 2/26/2024