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Catalog Number Size Price
LS-B15972-120 120 µl (2 mg/ml) $460 
CD207 / Langerin Antibody - Human Skin Langerhans Cells: Formalin-Fixed, Paraffin-Embedded (FFPE)

PathPlus™ Polyclonal Rabbit anti‑Human CD207 / Langerin Antibody (IHC) LS‑B15972

PathPlus™ Polyclonal Rabbit anti‑Human CD207 / Langerin Antibody (IHC) LS‑B15972

Note: This antibody replaces LS-C761260
Antibody:
CD207 / Langerin Rabbit anti-Human Polyclonal Antibody
Application:
IHC
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-B15972-120
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
CD207 / Langerin Rabbit anti-Human Polyclonal Antibody
Application:
IHC
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified

Specifications

Description
CD207 (also called langerin) is a calcium-dependent lectin with binding specific for mannose. It is the major cell-surface receptor for Candida species, Saccharomyces species, and Malassezia furfur on Langerhans cells (dendritic cells of the epidermis and mucosa). It has been proposed that mannose binding leads to antigen internalization into cytoplasmic Birbeck granules in Langerhans cells, comprising a nonclassical antigen-processing pathway. CD207 is expressed in Langerhans cells. It is also expressed in gliomas (astrocytoma, malignant ependymoma) but not normal brain. Staining is used to identify Langerhans cells. References: Immunity. 2000;12(1):71-81. PMID: 10661407; Immunol Res. 2003;28(2):93-107. doi: 10.1385/IR:28:2:93; Mol Immunol. 2010;47(6):1216-1225. doi: 10.1016/j.molimm.2009.12.016; Cell Mol Immunol. 2017;14(4):360-370. doi: 10.1038/cmi.2015.87; J Biol Chem. 2010;285(9):6390-6400. doi: 10.1074/jbc.M109.041863.
Target
Human CD207 / Langerin
Synonyms
CD207 | CD207 antigen, langerin | CD207 antigen | CD207 molecule, langerin | CLEC4K | Langerin
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Affinity purification
Modifications
Unmodified
Immunogen
Recombinant Mouse C-type lectin domain family 4 member K protein (63-331AA)
Applications
  • IHC (10 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Applications should be user optimized.
Presentation
PBS, pH 7.4., 0.02% Sodium Azide, 50% Glycerol
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CD207 / Langerin
Q9UJ71 NM_015717 NP_056532.4

Validation

CD207 / Langerin Antibody - Human Skin Langerhans Cells: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin Langerhans Cells: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin Langerhans Cells: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ CD207 / Langerin Antibody for IHC LS-B15972 has an LSBio Rating of
Laboratory Validation Score (5)

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 3/1/2024