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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-A804-50 50 µg (1 mg/ml) $425 
CXCR2 Antibody - Colon, Carcinoma
CXCR2 Antibody - Lung, Non Small-Cell Carcinoma
CXCR2 Antibody - Ovary, Carcinoma
CXCR2 Antibody - Breast, Carcinoma
CXCR2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
CXCR2 Antibody - Human Neutrophils: Formalin-Fixed, Paraffin-Embedded (FFPE)
CXCR2 Antibody - Colon, Carcinoma
CXCR2 Antibody - Lung, Non Small-Cell Carcinoma
CXCR2 Antibody - Ovary, Carcinoma
CXCR2 Antibody - Breast, Carcinoma
CXCR2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
CXCR2 Antibody - Human Neutrophils: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PathPlus™ Polyclonal Rabbit anti‑Human CXCR2 Antibody (Extracellular Domain, IHC) LS‑A804

PathPlus™ Polyclonal Rabbit anti‑Human CXCR2 Antibody (Extracellular Domain, IHC) LS‑A804

Antibody:
Rabbit Polyclonal to Human CXCR2
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A804-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human CXCR2
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CXCR2 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human CXCR2
Synonyms
CXCR2 | CDw128b | CD182 antigen | CMKAR2 | CXCR-2 | CD182 | CXC-R2 | IL-8R B | Il-8 receptor b | IL-8 receptor type 2 | Il-8rb | IL8R2 | IL8RB | Interleukin-8 receptor type B | GRO/MGSA receptor | Interleukin 8 receptor beta | Interleukin 8 receptor, beta | Chemokine (CXC) receptor 2 | IL8RA | Interleukin 8 receptor B | Interleukin 8 receptor type 2
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 15 amino acid peptide from 2nd extracellular domain of human CXCR2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Monkey (100%); Gorilla (80%).
Blocking Peptide
LS-E39765 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A804. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Extracellular Domain
Specificity
Human CXCR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CXCR2
P25025 nm_001557 NP_001548.1

Validation

CXCR2 Antibody - Colon, Carcinoma
Colon, Carcinoma
Colon, Carcinoma

CXCR2 Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

CXCR2 Antibody - Ovary, Carcinoma
Ovary, Carcinoma
Ovary, Carcinoma

CXCR2 Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

CXCR2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

CXCR2 Antibody - Human Neutrophils: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Neutrophils: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Neutrophils: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ CXCR2 Antibody (Extracellular Domain) for IHC LS-A804 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 7/3/2020