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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CXCR2

chemokine (C-X-C motif) receptor 2

CXCR2 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: chemokine (C-X-C motif) receptor 2
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR2, CDw128b, CD182 antigen, CMKAR2, CXCR-2, CD182, CXC-R2, IL-8R B, Il-8 receptor b, IL-8 receptor type 2, Il-8rb, IL8R2, IL8RB, Interleukin-8 receptor type B, GRO/MGSA receptor, Interleukin 8 receptor beta, Interleukin 8 receptor, beta, Chemokine (CXC) receptor 2, IL8RA, Interleukin 8 receptor B, Interleukin 8 receptor type 2
Target Sequences: nm_001557 NP_001548.1 P25025

Publications (4)

1
IL-8-mediated angiogenic responses of endothelial cells to lipid antigen activation of iNKT cells depend on EGFR transactivation. Kyriakakis E, Cavallari M, Pfaff D, Fabbro D, Mestan J, Philippova M, De Libero G, Erne P, Resink TJ. Journal of leukocyte biology. 2011 90:929-39. [PubMed:21807744]
2
CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer. Nishi T, Takeuchi H, Matsuda S, Ogura M, Kawakubo H, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Kitagawa Y. World journal of surgical oncology. 2015 13:232. (IHC-P; Human) [Full Text Article] [PubMed:26231560] [PMC:PMC4522106]
3
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C171552.
4
Clinical significance of CXCL-8/CXCR-2 network in esophageal squamous cell carcinoma. Ogura M, Takeuchi H, Kawakubo H, Nishi T, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Miyasho T, Yamada S, Kitagawa Y. Surgery. 2013 Sep;154:512-20. [Full Text Article] [PubMed:23972657] Related Antibodies: LS-A803.
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Filtered by: None
Target
CXCR2 (77)
Reactivity
Human (67)
Mouse (19)
Rat (4)
Chimpanzee (3)
Dog (2)
Monkey (9)
Application
IHC (37)
IHC-Fr (1)
IHC-P (31)
WB (44)
Flo (4)
ELISA (16)
ICC (11)
IF (11)
IP (12)
Peptide-ELISA (3)
Host
rabbit (70)
mouse (6)
goat (1)
Isotype
IgG (21)
IgG1 (2)
IgG1,k (2)
IgG2b,k (1)
Clonality
monoclonal mc (5)
polyclonal pc (72)
Clone
3M9 (1)
5E8-C7-F10 (2)
Format
AP Conjugated (3)
APC (2)
APC Conjugated (5)
Azide-free (3)
Biotin Conjugated (7)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (7)
HRP Conjugated (7)
Magnetic beads Conjugated (1)
PE Conjugated (6)
Sepharose Conjugated (1)
Unconjugated (36)
Epitope
N-Terminus (18)
Extracellular Domain (7)
pSer347 (4)
Internal (3)
290-370 aa (2)
aa196-212 (2)
1-50 aa, N-terminal (1)
C-Terminus (1)
aa3-13 (1)
aa311-360 (1)
aa7-38 (1)
Publications
No (75)
Yes (2)
Showing 1-25 of 77 results

IHC-plus™ CXCR2 Antibody (N-Terminus) LS-A803
Publications (1)
Publications (1)
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CXCR2 Antibody (N-Terminus, Biotin) LS-A107317
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CXCR2 Antibody (N-Terminus, PE) LS-A107320
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CXCR2 Antibody (N-Terminus, AP) LS-A107315
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CXCR2 Antibody (N-Terminus, Azide-free, HRP) LS-A107319
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CXCR2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CXCR2 Antibody LS-B2309
Mouse Monoclonal (IgG1) to Human CXCR2
Human
Flo, IHC, IHC-P
Unconjugated
50µg 1mg/ml  $495.00
Anti-CXCR2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

IHC-plus™ CXCR2 Antibody (N-Terminus) LS-A802
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-CXCR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ CXCR2 Antibody (N-Terminus) LS-B5733
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P, WB
Unconjugated
100µl 0.5mg/ml  $485.00
Anti-CXCR2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
CXCR2 / IL8RB antibody Western blot of PANC1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

CXCR2 Antibody (aa196-212) LS-C388292
Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Rat, Human
WB
Unconjugated
100µg  $435.00
Western blot testing of CXCR2 antibody and Lane 1: rat spleen; 2: rat kidney; 3: rat brain; 4: mouse testis; 5: HEPA; 6: mouse brain at 50ug; Predicted size: 41KD; Observed size: 41KD
Western blot testing of CXCR2 antibody and Lane 1: human rectal cancer tissue lysate; 2: human rectal cancer tissue lysate

CXCR2 Antibody (Internal) LS-C171552
Publications (1)
Publications (1)
Rabbit Polyclonal to Human CXCR2
Rat, Human
WB
Unconjugated
100µg 1mg/ml  $295.00
Western blot Image

CXCR2 Antibody (C-Terminus) LS-C358964
Rabbit Polyclonal to Human CXCR2
Dog, Human
ICC, IF, WB
Unconjugated
30µl 1mg/ml  $205.00; 100µl 1mg/ml  $245.00; 200µl 1mg/ml  $305.00
Immunofluorescent analysis of CD182 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 ??C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Western blot analysis of CD182 expression in HeLa (A); HL60 (B) whole cell lysates.

IHC-plus™ CXCR2 Antibody (Extracellular Domain) LS-A804
Rabbit Polyclonal to Human CXCR2
Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Neutrophils: Formalin-Fixed, Paraffin-Embedded (FFPE)

CXCR2 Antibody (phospho-Ser347) LS-C358963
Rabbit Polyclonal to Human CXCR2
Mouse, Dog, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30µl 1mg/ml  $215.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $325.00
Immunohistochemical analysis of CD182 (pS347) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of CD182 (pS347) staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 ??C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

CXCR2 Antibody (290-370 aa) LS-C384131
Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
ELISA, IF
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

CXCR2 Antibody (aa311-360) LS-C117964
Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
IF, Peptide-ELISA
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunofluorescence analysis of HepG2 cells, using IL-8R beta/CDw128 beta Antibody. The picture on the right is blocked with the synthesized peptide.

CXCR2 Antibody (aa3-13) LS-C154965
Goat Polyclonal to Mouse CXCR2
Mouse
Peptide-ELISA, WB
Unconjugated
100µg 0.5mg/ml  $405.00
CXCR2 antibody (0.3 ug/ml) staining of Mouse Colon lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CXCR2 Antibody (phospho-Ser347) LS-C808481
Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunohistochemistry Image

CXCR2 Antibody LS-C804304
Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

CXCR2 Antibody (phospho-Ser347) LS-C416614
Rabbit Polyclonal to Human CXCR2
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
100µg  $305.00
Western blot of IL-8R beta/CDw128 beta phosphorylation expression in PMA treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

CXCR2 Antibody (phospho-Ser347) LS-C199118
Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using IL-8R beta/CDw128 beta (Phospho-Ser347) Antibody. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of COS7 cells, using IL-8R beta/CDw128 beta (Phospho-Ser347) Antibody. The picture on the right is blocked with the phospho peptide.

CXCR2 Antibody (290-370 aa) LS-C381535
Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Phospho-IL8Rbeta (S347) antibody

CXCR2 Antibody LS-C8056
Mouse Monoclonal (IgG1) to Human CXCR2
Human
Flo, IHC, IHC-Fr, WB
Unconjugated
100µg  $475.00

CXCR2 Antibody LS-C753176
Rabbit Polyclonal (IgG) to Human CXCR2
Human
ELISA, IF, IP, WB
Unconjugated
100µg  $375.00

CXCR2 Antibody LS-C769323
Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Human
ELISA, IF, IHC-P, WB
Unconjugated
20µl 1mg/ml  $205.00; 60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

CXCR2 Antibody LS-C202991
Rabbit Polyclonal (IgG) to Human CXCR2
ELISA, IHC, IHC-P, WB
Unconjugated
40µg 80µl 0.5mg/ml  $245.00
Immunohistochemistry of human spleen tissue slide (Paraffin embedded) using Rabbit Anti-CXCR2 Polyclonal Antibody.
Immunohistochemistry negative control analysis of human spleen tissue slide (Paraffin embedded) using Purified Rabbit IgG (Whole molecule) Control
Showing 1-25 of 77 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).