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Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
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Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
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CXCR2

chemokine (C-X-C motif) receptor 2

CXCR2 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: chemokine (C-X-C motif) receptor 2
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR2, CDw128b, CD182 antigen, CMKAR2, CXCR-2, CD182, CXC-R2, IL-8R B, Il-8 receptor b, IL-8 receptor type 2, Il-8rb, IL8R2, IL8RB, Interleukin-8 receptor type B, GRO/MGSA receptor, Interleukin 8 receptor beta, Interleukin 8 receptor, beta, Chemokine (CXC) receptor 2, IL8RA, Interleukin 8 receptor B, Interleukin 8 receptor type 2
Target Sequences: nm_001557 NP_001548.1 P25025

Publications (4)

1
IL-8-mediated angiogenic responses of endothelial cells to lipid antigen activation of iNKT cells depend on EGFR transactivation. Kyriakakis E, Cavallari M, Pfaff D, Fabbro D, Mestan J, Philippova M, De Libero G, Erne P, Resink TJ. Journal of leukocyte biology. 2011 90:929-39. [PubMed:21807744]
2
CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer. Nishi T, Takeuchi H, Matsuda S, Ogura M, Kawakubo H, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Kitagawa Y. World journal of surgical oncology. 2015 13:232. (IHC-P; Human) [Full Text Article] [PubMed:26231560] [PMC:PMC4522106]
3
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C171552.
4
Clinical significance of CXCL-8/CXCR-2 network in esophageal squamous cell carcinoma. Ogura M, Takeuchi H, Kawakubo H, Nishi T, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Miyasho T, Yamada S, Kitagawa Y. Surgery. 2013 Sep;154:512-20. [Full Text Article] [PubMed:23972657] Related Antibodies: LS-A803.
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CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
Biotin Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
FITC Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
AP Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
APC Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
PE Conjugated
100 µl/$650
CXCR2 Antibody - Breast, Carcinoma
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Cancer
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Rabbit Polyclonal to Human CXCR2
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100 µl/$650
CXCR2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human, Monkey
IHC, IHC-P
FITC Conjugated
100 µl/$650
CXCR2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human, Monkey
IHC, IHC-P
AP Conjugated
100 µl/$650
CXCR2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human, Monkey
IHC, IHC-P
APC Conjugated
100 µl/$650
CXCR2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100 µl/$650
CXCR2 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human, Monkey
IHC, IHC-P
PE Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
Biotin Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
FITC Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
AP Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
APC Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P
PE Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal (IgG1) to Human CXCR2
Human
Flo, IHC, IHC-P
Unconjugated
50 µg/$495
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human CXCR2
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CXCR2 Antibody - Western blot testing of CXCR2 antibody and Lane 1: rat spleen; 2: rat kidney; 3: rat brain; 4: mouse testis; 5: HEPA; 6: mouse brain at 50ug; Predicted size: 41KD; Observed size: 41KD
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Rabbit Polyclonal (IgG) to Human CXCR2
Mouse, Rat, Human
WB
Unconjugated
100 µg/$435
CXCR2 Antibody
Select
Rabbit Polyclonal to Human CXCR2
Rat, Human
WB
Unconjugated
100 µg/$295
Viewing 1-25 of 80 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).