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Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CXCR2

chemokine (C-X-C motif) receptor 2

CXCR2 is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Gene Name: chemokine (C-X-C motif) receptor 2
Family/Subfamily: GPCR , Chemokine
Synonyms: CXCR2, CDw128b, CD182 antigen, CMKAR2, CXCR-2, CD182, CXC-R2, IL-8R B, Il-8 receptor b, IL-8 receptor type 2, Il-8rb, IL8R2, IL8RB, Interleukin-8 receptor type B, GRO/MGSA receptor, Interleukin 8 receptor beta, Interleukin 8 receptor, beta, Chemokine (CXC) receptor 2, IL8RA, Interleukin 8 receptor B, Interleukin 8 receptor type 2
Target Sequences: nm_001557 NP_001548.1 P25025

Publications (4)

1
IL-8-mediated angiogenic responses of endothelial cells to lipid antigen activation of iNKT cells depend on EGFR transactivation. Kyriakakis E, Cavallari M, Pfaff D, Fabbro D, Mestan J, Philippova M, De Libero G, Erne P, Resink TJ. Journal of leukocyte biology. 2011 90:929-39. [PubMed:21807744]
2
CXCR2 expression and postoperative complications affect long-term survival in patients with esophageal cancer. Nishi T, Takeuchi H, Matsuda S, Ogura M, Kawakubo H, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Kitagawa Y. World journal of surgical oncology. 2015 13:232. (IHC-P; Human) [Full Text Article] [PubMed:26231560] [PMC:PMC4522106]
3
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C171552.
4
Clinical significance of CXCL-8/CXCR-2 network in esophageal squamous cell carcinoma. Ogura M, Takeuchi H, Kawakubo H, Nishi T, Fukuda K, Nakamura R, Takahashi T, Wada N, Saikawa Y, Omori T, Miyasho T, Yamada S, Kitagawa Y. Surgery. 2013 Sep;154:512-20. [Full Text Article] [PubMed:23972657] Related Antibodies: LS-A803.
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Products
Antibodies (79)
Primary (79)
CXCR2 (79)
Human (68)
Mouse (21)
Rat (4)
Chimpanzee (3)
Dog (2)
Monkey (9)
IHC (40)
IHC-Fr (1)
IHC-P (32)
WB (46)
Flo (4)
ELISA (18)
ICC (12)
IF (12)
IP (12)
Peptide-ELISA (3)
rabbit (70)
mouse (6)
goat (1)
rabbit-new zealand white (2)
Product Group
GPCR Database Antibodies (21)
IHCPlus (21)
PathPlus Cancer (2)
IgG (22)
IgG1 (4)
IgG2b,k (1)
monoclonal mc (5)
polyclonal pc (74)
3M9 (1)
5F7A11 (1)
7E9H12 (1)
AP Conjugated (3)
APC (2)
APC Conjugated (5)
Azide-free (3)
Biotin Conjugated (7)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (7)
HRP Conjugated (7)
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PE Conjugated (5)
Sepharose Conjugated (1)
Unconjugated (39)
N-Terminus (18)
Extracellular Domain (7)
pSer347 (5)
Internal (3)
290-370 aa (2)
aa196-212 (2)
1-50 aa, N-terminal (1)
C-Terminus (1)
aa2-50 (1)
aa3-13 (1)
aa311-360 (1)
aa7-38 (1)
No (77)
Yes (2)
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer
CXCR2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
CXCR2 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Human
IHC, IHC-P
Biotin Conjugated
100 µl/$650
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
CXCR2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CXCR2 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-P
Unconjugated
50 µg/$495
CXCR2 Antibody - Anti-CXCR2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CXCR2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CXCR2 Antibody - Western blot testing of CXCR2 antibody and Lane 1: rat spleen; 2: rat kidney; 3: rat brain; 4: mouse testis; 5: HEPA; 6: mouse brain at 50ug; Predicted size: 41KD; Observed size: 41KD
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CXCR2 Rabbit anti-Human Polyclonal (aa196-212) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$435
CXCR2 Antibody
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CXCR2 Rabbit anti-Human Polyclonal (Internal) Antibody
Rat, Human
WB
Unconjugated
100 µg/$295
CXCR2 Antibody - Breast, Carcinoma
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Cancer
Fast Shipping
CXCR2 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
CXCR2 Antibody - Immunofluorescent analysis of CD182 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 ??C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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CXCR2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Human
ICC, IF, WB
Unconjugated
30 µl/$205; 100 µl/$245; 200 µl/$305
CXCR2 Antibody - CXCR2 antibody (0.3 ug/ml) staining of Mouse Colon lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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CXCR2 Goat anti-Mouse Polyclonal (aa3-13) Antibody
Mouse
Peptide-ELISA, WB
Unconjugated
100 µg/$405
CXCR2 Antibody - Immunohistochemical analysis of CD182 (pS347) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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CXCR2 Rabbit anti-Human Polyclonal (pSer347) Antibody
Mouse, Dog, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$215; 100 µl/$265; 200 µl/$325
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CXCR2 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-Fr, WB
Unconjugated
100 µg/$485
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CXCR2 Rabbit anti-Human Polyclonal (290-370 aa) Antibody
Mouse, Human
ELISA, IF
Unconjugated
50 µl/$235; 100 µl/$265; 200 µl/$335
CXCR2 Antibody - Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CD182 mouse mAb with DAB staining.
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CXCR2 Mouse anti-Human Monoclonal (5F7A11) Antibody
Human
ELISA, Flo, ICC, IHC, WB
Unconjugated
100 µg/$365
CXCR2 Antibody - Immunofluorescence analysis of HepG2 cells, using IL-8R beta/CDw128 beta Antibody. The picture on the right is blocked with the synthesized peptide.
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CXCR2 Rabbit anti-Human Polyclonal (aa311-360) Antibody
Mouse, Human
IF, Peptide-ELISA
Unconjugated
50 µl/$265; 100 µl/$325
CXCR2 Antibody - Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CD182 mouse mAb with DAB staining.
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CXCR2 Mouse anti-Human Monoclonal (7E9H12) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$365
CXCR2 Antibody - 1:100 staining mouse intestine tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CXCR2 Rabbit anti-Human Polyclonal (pSer347) Antibody
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100 µl/$325; 200 µl/$375
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CXCR2 Rabbit anti-Human Polyclonal (aa196-212) Antibody
Human, Monkey
WB
Unconjugated
100 µg/$590
CXCR2 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using IL-8Rß/CDw128ß (Phospho-Ser347) antibody.
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CXCR2 Rabbit anti-Human Polyclonal (pSer347) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$305
CXCR2 Antibody - 1:100 staining human lymphoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CXCR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$325; 200 µl/$375
CXCR2 Antibody - Western blot of IL-8R beta/CDw128 beta phosphorylation expression in PMA treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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CXCR2 Rabbit anti-Human Polyclonal (pSer347) Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$255; 100 µg/$305
CXCR2 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using IL-8R beta/CDw128 beta (Phospho-Ser347) Antibody. The picture on the right is blocked with the phospho peptide.
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CXCR2 Rabbit anti-Human Polyclonal (pSer347) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$265; 100 µl/$325
CXCR2 Antibody - Western blot of Phospho-IL8Rbeta (S347) antibody
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CXCR2 Rabbit anti-Human Polyclonal (290-370 aa) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$235; 100 µl/$265; 200 µl/$335
Select
CXCR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$375
CXCR2 Antibody - Immunohistochemistry of human spleen tissue slide (Paraffin embedded) using Rabbit Anti-CXCR2 Polyclonal Antibody.
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CXCR2 Rabbit anti-Human Polyclonal Antibody
ELISA, IHC, IHC-P, WB
Unconjugated
40 µg/$245
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).