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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A6731-50 50 µg (1 mg/ml) $425 
CALCRL / CGRP Receptor Antibody - Breast, adenocarcinoma
CALCRL / CGRP Receptor Antibody - Vessel, endothelium
CALCRL / CGRP Receptor Antibody - Brain Amygdala Neurons
CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Anti-CALCRL antibody IHC of human colon, submucosal plexus and submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Bone, Osteosarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Breast, adenocarcinoma
CALCRL / CGRP Receptor Antibody - Vessel, endothelium
CALCRL / CGRP Receptor Antibody - Brain Amygdala Neurons
CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Anti-CALCRL antibody IHC of human colon, submucosal plexus and submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Bone, Osteosarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human CALCRL / CGRP Receptor Antibody (Cytoplasmic Domain, IHC) LS‑A6731

PathPlus™ Polyclonal Rabbit anti‑Human CALCRL / CGRP Receptor Antibody (Cytoplasmic Domain, IHC) LS‑A6731

Antibody:
Rabbit Polyclonal to Human CALCRL / CGRP Receptor
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Rat, Bovine, Dog, Goat, Hamster, Horse, Pig, Rabbit, Xenopus
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A6731-50
50 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human CALCRL / CGRP Receptor
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Rat, Bovine, Dog, Goat, Hamster, Horse, Pig, Rabbit, Xenopus
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CALCRL (Calcitonin receptor-like receptor, CRLR) is a G protein-coupled receptor that binds CGRP (calcitonin gene-related peptide) and ADM (adrenomedullin) in complex with RAMP proteins. RAMP-CALCRL complexes binding either of these peptides activate cyclic AMP signaling. In nerve cells, CALCRL is involved in a CGRP cascade that can suppress the immune response and the recruitment of neutrophils in clean injuries, a process that can be counter-productive in cases of necrotizing fasciitis or unclean wounds. CGRP itself is involved in pain signal transmission, pain-induced threat memory, taste memory and appetite regulation in neurons in the central nervous system, and antagonists to both CGRP and its receptor CALCRL are of interest in migraine therapies. In immunohistochemistry, CALCRL has membranous and cytoplasmic positivity in all tissues, including the microvascular endothelium. References: Cell. 2018 May 17;173(5):1083-1097.e22, PMID: 29754819; Current Protein & Peptide Science. 14 (5): 386–92, PMID: 23745702; Cell. 2018. 41(5): 280-293, DOI: 10.1016/j.tins.2018.03.007; J Clin Pathol. 2004 Feb; 57(2): 172–176, PMID: 14747444; J Biol Chem. 2005 Mar 11;280(10):9297-307, PMID: 15613468;
Target
Human CALCRL / CGRP Receptor
Synonyms
CALCRL | CGRP type 1 receptor | Cgrp1 receptor | CRLR | Calcitonin receptor-like | CGRP receptor | CGRPR
Host
Rabbit
Reactivity
Human, Monkey, Rat, Bovine, Dog, Goat, Hamster, Horse, Pig, Rabbit, Xenopus (tested or 100% immunogen sequence identity)
Predicted
Mouse, Bat, Guinea pig, Zebrafish (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (34 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human CALCRL. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Rat, Goat, Hamster, Panda, Dog, Bovine, Horse, Rabbit, Pig, Opossum, Xenopus (100%); Mouse, Elephant, Bat, Guinea pig, Stickleback, Pufferfish, Zebrafish (94%); Turkey, Chicken (81%).
Blocking Peptide
LS-E29174 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A6731. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
Cytoplasmic Domain
Specificity
Human CALCRL. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CALCR (56%).
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CALCRL / CGRP Receptor
Q16602 NM_005795 NP_005786.1

Validation

CALCRL / CGRP Receptor Antibody - Breast, adenocarcinoma
Breast, adenocarcinoma
Breast, adenocarcinoma

CALCRL / CGRP Receptor Antibody - Vessel, endothelium
Vessel, endothelium
Vessel, endothelium

CALCRL / CGRP Receptor Antibody - Brain Amygdala Neurons
Brain Amygdala Neurons
Brain Amygdala Neurons

CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL / CGRP Receptor antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL / CGRP Receptor antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CALCRL / CGRP Receptor Antibody - Anti-CALCRL antibody IHC of human colon, submucosal plexus and submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL antibody IHC of human colon, submucosal plexus and submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL antibody IHC of human colon, submucosal plexus and submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Bone, Osteosarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL / CGRP Receptor antibody IHC of human Bone, Osteosarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL / CGRP Receptor antibody IHC of human Bone, Osteosarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ CALCRL / CGRP Receptor Antibody (Cytoplasmic Domain) for IHC LS-A6731 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 6/5/2020