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Catalog Number Size Price
LS-A6755-50 50 µg (1 mg/ml) $440 
CALCRL / CGRP Receptor Antibody - lung, alveoli
CALCRL / CGRP Receptor Antibody - prostate, adenocarcinoma
CALCRL / CGRP Receptor Antibody - Brain Hypothalamus Neurons
CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Bone, Osteosarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Anti-CALCRL antibody IHC of human colon, submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - lung, alveoli
CALCRL / CGRP Receptor Antibody - prostate, adenocarcinoma
CALCRL / CGRP Receptor Antibody - Brain Hypothalamus Neurons
CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Bone, Osteosarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCRL / CGRP Receptor Antibody - Anti-CALCRL antibody IHC of human colon, submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human CALCRL / CGRP Receptor Antibody (N‑Terminus, IHC) LS‑A6755

PathPlus™ Polyclonal Rabbit anti‑Human CALCRL / CGRP Receptor Antibody (N‑Terminus, IHC) LS‑A6755

Antibody:
CALCRL / CGRP Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$440
LS-A6755-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
CALCRL / CGRP Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
CALCRL (Calcitonin receptor-like receptor, CRLR) is a G protein-coupled receptor that binds CGRP (calcitonin gene-related peptide) and ADM (adrenomedullin) in complex with RAMP proteins. RAMP-CALCRL complexes binding either of these peptides activate cyclic AMP signaling. In nerve cells, CALCRL is involved in a CGRP cascade that can suppress the immune response and the recruitment of neutrophils in clean injuries, a process that can be counter-productive in cases of necrotizing fasciitis or unclean wounds. CGRP itself is involved in pain signal transmission, pain-induced threat memory, taste memory and appetite regulation in neurons in the central nervous system, and antagonists to both CGRP and its receptor CALCRL are of interest in migraine therapies. In immunohistochemistry, CALCRL has membranous and cytoplasmic positivity in all tissues, including the microvascular endothelium. References: Cell. 2018 May 17;173(5):1083-1097.e22, PMID: 29754819; Current Protein & Peptide Science. 14 (5): 386–92, PMID: 23745702; Cell. 2018. 41(5): 280-293, DOI: 10.1016/j.tins.2018.03.007; J Clin Pathol. 2004 Feb; 57(2): 172–176, PMID: 14747444; J Biol Chem. 2005 Mar 11;280(10):9297-307, PMID: 15613468;
Target
Human CALCRL / CGRP Receptor
Synonyms
CALCRL | CGRP type 1 receptor | Cgrp1 receptor | CRLR | Calcitonin receptor-like | CGRP receptor | CGRPR
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Mouse, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 15 amino acid peptide from N-Terminus extracellular domain of human CALCRL. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%); Marmoset, Mouse, Rabbit (93%); Rat, Panda, Dog, Horse, Pig (87%); Goat, Bovine (80%).
Epitope
N-Terminus
Specificity
Human CALCRL. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (16 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CALCRL / CGRP Receptor
Q16602 NM_005795 NP_005786.1

Validation

CALCRL / CGRP Receptor Antibody - lung, alveoli
lung, alveoli
lung, alveoli

CALCRL / CGRP Receptor Antibody - prostate, adenocarcinoma
prostate, adenocarcinoma
prostate, adenocarcinoma

CALCRL / CGRP Receptor Antibody - Brain Hypothalamus Neurons
Brain Hypothalamus Neurons
Brain Hypothalamus Neurons

CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Bone, Osteosarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL / CGRP Receptor antibody IHC of human Bone, Osteosarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL / CGRP Receptor antibody IHC of human Bone, Osteosarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL / CGRP Receptor antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL / CGRP Receptor antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CALCRL / CGRP Receptor Antibody - Anti-CALCRL  / CGRP Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL / CGRP Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL / CGRP Receptor antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CALCRL / CGRP Receptor Antibody - Anti-CALCRL antibody IHC of human colon, submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL antibody IHC of human colon, submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCRL antibody IHC of human colon, submucosal vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ CALCRL / CGRP Receptor Antibody (N-Terminus) for IHC LS-A6755 has an LSBio Rating of
Laboratory Validation Score (5)

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Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/28/2021