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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TOPBP1

topoisomerase (DNA) II binding protein 1

Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.

Gene Name: topoisomerase (DNA) II binding protein 1
Family/Subfamily: DNA repair
Synonyms: TOPBP1, KIAA0259, TOP2BP1
Target Sequences: NM_007027 NP_008958.2 Q92547

Viewing 1-25 of 53 items
TOPBP1 Antibody - Western Blot; Sample: Recombinant protein.
Select
Rabbit Polyclonal to Mouse TOPBP1
Mouse
WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $265.00; 200µl   0.5mg/ml   $305.00; 1ml   0.5mg/ml   $545.00
TOPBP1 Antibody
Select
Rabbit Polyclonal to Human TOPBP1
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
TOPBP1 Antibody - Immunohistochemistry of paraffin-embedded mouse heart.
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Mouse, Human
IF, IHC, WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00
TOPBP1 Antibody - Immunohistochemistry of paraffin-embedded mouse lung using TOPBP1 antibody at dilution of 1:100 (40x lens).
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00
TOPBP1 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
ELISA, IHC, IHC-P
Unconjugated
50µl   $285.00; 100µl   $385.00
Select
Mouse Monoclonal [clone 11n195] (IgG2b) to Human TOPBP1
Human
ICC, WB
Unconjugated
100µg   $650.00
Select
Rabbit Polyclonal to Human TOPBP1
Human
IF, WB
Unconjugated
100µl   1mg/ml   $385.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal to Human TOPBP1
Mouse, Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
TOPBP1 Antibody
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Mouse, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
DB, ELISA
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
DB, ELISA
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
DB, ELISA
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
DB, ELISA
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
DB, ELISA
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
DB, ELISA
PE Conjugated
200µl   $740.00
TOPBP1 Antibody - Detection of Mouse T op BP1 by Western Blot. Samples: Whole cell lysate from TCMK-1 (15 and 50 ug) cells. Antibodies: Affinity purified rabbit anti-TopBP1 antibody used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Select
Rabbit Polyclonal (IgG) to Human TOPBP1
Mouse, Human
IP, WB
Unconjugated
100µl   1mg/ml   $395.00
TOPBP1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY TOPBP1. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI5C12] (IgG2a) to Human TOPBP1
Human
WB
Unconjugated
100µl   1mg/ml   $345.00

Viewing 1-25 of 53 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).