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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TOPBP1

topoisomerase (DNA) II binding protein 1

Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.

Gene Name: topoisomerase (DNA) II binding protein 1
Family/Subfamily: DNA repair
Synonyms: TOPBP1, KIAA0259, TOP2BP1
Target Sequences: NM_007027 NP_008958.2 Q92547

Filtered By: None
Target
TOPBP1 (49)
Reactivity
Human (33)
Mouse (12)
Rat (10)
Application
IHC (28)
IHC-P (2)
WB (40)
DB (8)
ELISA (15)
ICC (2)
IF (3)
IP (1)
PLA (1)
Host
rabbit (47)
mouse (1)
sheep (1)
Isotype
IgG (21)
IgG2b (1)
Clonality
monoclonal mc (1)
polyclonal pc (48)
Clone
11n195 (1)
Format
AP Conjugated (2)
APC (3)
APC Conjugated (5)
Azide-free (2)
Biotin Conjugated (5)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (5)
Unconjugated (16)
Epitope
pSer1159 (8)
aa1114-1142 (7)
C-Terminus (1)
aa1187-1621 (1)
aa1192-1621 (1)
aa1253-1522 (1)
aa792-1064 (1)
Publications
No (49)
Showing 1-25 of 49 results

TOPBP1 Antibody LS-C668199
Rabbit Polyclonal to Human TOPBP1
Human
ICC IF IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Immunohistochemistry - Paraffin Image
Immunofluorescence Image
Immunohistochemistry - Paraffin Image
Immunofluorescence Image

TOPBP1 Antibody LS-C334288
Rabbit Polyclonal (IgG) to Human TOPBP1
Mouse, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Immunohistochemistry of paraffin-embedded mouse heart.
Immunohistochemistry of paraffin-embedded human colon carcinoma tissue.
Immunohistochemistry of paraffin-embedded mouse heart.
Immunohistochemistry of paraffin-embedded human colon carcinoma tissue.

TOPBP1 Antibody LS-C747670
Rabbit Polyclonal (IgG) to Human TOPBP1
Mouse, Rat, Human
IHC WB
Unconjugated
50µl  $235.00
Immunohistochemistry of paraffin-embedded mouse lung using TOPBP1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat lung using TOPBP1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse lung using TOPBP1 antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat lung using TOPBP1 antibody at dilution of 1:100 (40x lens).

TOPBP1 Antibody (aa1253-1522) LS-C378718
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
ELISA IHC IHC-P
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human placenta tissue using antibody at 1:100 dilution.

TOPBP1 Antibody (aa1192-1621, clone 11n195) LS-C184913
Mouse Monoclonal [clone 11n195] (IgG2b) to Human TOPBP1
Human
ICC WB
Unconjugated
100µg 200µl  $620.00

TOPBP1 Antibody LS-C663420
Rabbit Polyclonal to Mouse TOPBP1
Mouse
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $545.00; 10ml 0.5mg/ml  $2,160.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (HRP) LS-C712764
Rabbit Polyclonal to Mouse TOPBP1
Mouse
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $295.00; 200µl  $345.00; 1ml  $695.00; 10ml  $2,805.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (Biotin) LS-C688105
Rabbit Polyclonal to Mouse TOPBP1
Mouse
IHC WB
Biotin Conjugated
20µl  $205.00; 100µl  $275.00; 200µl  $315.00; 1ml  $590.00; 10ml  $2,370.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (FITC) LS-C695022
Rabbit Polyclonal to Mouse TOPBP1
Mouse
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $335.00; 1ml  $650.00; 10ml  $2,580.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (Cy3) LS-C703739
Rabbit Polyclonal to Mouse TOPBP1
Mouse
IHC WB
Cy3 Conjugated
20µl  $245.00; 100µl  $365.00; 200µl  $445.00; 1ml  $1,080.00; 10ml  $4,320.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (APC) LS-C718446
Rabbit Polyclonal to Mouse TOPBP1
Mouse
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $315.00; 200µl  $375.00; 1ml  $815.00; 10ml  $6,180.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (PE) LS-C726821
Rabbit Polyclonal to Mouse TOPBP1
Mouse
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $335.00; 1ml  $650.00; 10ml  $2,580.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (APC, Cy7) LS-C735746
Rabbit Polyclonal to Mouse TOPBP1
Mouse
IHC WB
APC, Cy7 Conjugated
20µl  $285.00; 100µl  $465.00; 200µl  $650.00; 1ml  $1,620.00; 10ml  $6,480.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody LS-C341868
Rabbit Polyclonal to Human TOPBP1
Human
IF WB
Unconjugated
100µl 1mg/ml  $385.00

TOPBP1 Antibody LS-C663417
Rabbit Polyclonal to Human TOPBP1
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (HRP) LS-C712759
Rabbit Polyclonal to Human TOPBP1
Human
IHC WB
HRP Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $680.00; 10ml  $2,730.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (Biotin) LS-C688104
Rabbit Polyclonal to Human TOPBP1
Human
IHC WB
Biotin Conjugated
20µl  $205.00; 100µl  $265.00; 200µl  $315.00; 1ml  $575.00; 10ml  $2,310.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (Cy3) LS-C703738
Rabbit Polyclonal to Human TOPBP1
Human
IHC WB
Cy3 Conjugated
20µl  $245.00; 100µl  $355.00; 200µl  $445.00; 1ml  $1,050.00; 10ml  $4,200.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (APC, Cy7) LS-C735745
Rabbit Polyclonal to Human TOPBP1
Human
IHC WB
APC, Cy7 Conjugated
20µl  $285.00; 100µl  $455.00; 200µl  $635.00; 1ml  $1,575.00; 10ml  $6,300.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (PE) LS-C726823
Rabbit Polyclonal to Human TOPBP1
Human
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,520.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (APC) LS-C741181
Rabbit Polyclonal to Human TOPBP1
Human
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $305.00; 200µl  $375.00; 1ml  $785.00
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.
Western Blot; Sample: Recombinant protein.

TOPBP1 Antibody (aa1114-1142) LS-C325868
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
ELISA WB
Unconjugated
200µl  $530.00

TOPBP1 Antibody (C-Terminus) LS-C287042
Rabbit Polyclonal (IgG) to Human TOPBP1
Mouse, Human
IP PLA WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human TopBP1 by Western Blot and Immunoprecipitation. Sample: Whole cell lysate (50 ug for WB; 0.5 mg for IP) from HeLa cells. Antibody: Affinity purified rabbit anti-TopBP1 used at 0.5 ug/ml for WB and 2 ug/mg lysate for IP. Detection: Chemiluminescence.
Detection of Mouse T op BP1 by Western Blot. Samples: Whole cell lysate from TCMK-1 (15 and 50 ug) cells. Antibodies: Affinity purified rabbit anti-TopBP1 antibody used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Detection of Human TopBP1 by Western Blot and Immunoprecipitation. Sample: Whole cell lysate (50 ug for WB; 0.5 mg for IP) from HeLa cells. Antibody: Affinity purified rabbit anti-TopBP1 used at 0.5 ug/ml for WB and 2 ug/mg lysate for IP. Detection: Chemiluminescence.
Detection of Mouse T op BP1 by Western Blot. Samples: Whole cell lysate from TCMK-1 (15 and 50 ug) cells. Antibodies: Affinity purified rabbit anti-TopBP1 antibody used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

TOPBP1 Antibody (phospho-Ser1159) LS-C325866
Rabbit Polyclonal (IgG) to Human TOPBP1
Human
DB ELISA
Unconjugated
200µl  $530.00

TOPBP1 Antibody LS-C663928
Rabbit Polyclonal to Rat TOPBP1
Rat
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00; 10ml 0.5mg/ml  $2,280.00
Showing 1-25 of 49 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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