TOPBP1

topoisomerase (DNA) II binding protein 1

Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.

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Products

Antibodies (52)

Proteins (6)

Type

Over-Expression Lysate (2)

Primary (52)

Recombinant (4)

Target

TOPBP1 (58)

Reactivity

Human (36)

Mouse (16)

Rat (11)

Application

IHC (6)

IHC-P (2)

WB (44)

DB (7)

ELISA (14)

ICC (2)

IF (4)

IP (1)

Peptide-ELISA (1)

Host

rabbit (49)

mouse (2)

sheep (1)

Isotype

IgG (22)

IgG2a (1)

IgG2b (1)

Clonality

monoclonal mc (2)

polyclonal pc (50)

Clone

11n195 (1)

OTI5C12 (1)

Format

APC (3)

APC Conjugated (5)

Azide-free (2)

Biotin Conjugated (5)

Cy3 Conjugated (3)

Cy7 Conjugated (3)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (5)

Unconjugated (21)

Epitope

pSer1159 (7)

aa1114-1142 (6)

aa1187-1621 (1)

aa1192-1621 (1)

aa1253-1522 (1)

aa1400-C-term (1)

aa792-1064 (1)

aa892-1146 (1)

Publications

No (58)

Tag

GST, N-terminus (1)

His-T7, N-terminus (2)

Myc-DDK (Flag) (2)

Species

Human (3)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Select

TOPBP1 Antibody LS-C334288

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

TOPBP1 Antibody LS-C663420

Antibody:

TOPBP1 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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TOPBP1 Antibody LS-C668199

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

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TOPBP1 Antibody LS-C834309

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

TOPBP1 Antibody LS-C747670

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

TOPBP1 Antibody (aa1253-1522) LS-C378718

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (aa1253-1522) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

TOPBP1 Antibody (aa1192-1621, clone 11n195) LS-C184913

Antibody:

TOPBP1 Mouse anti-Human Monoclonal (aa1192-1621) (11n195) Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µg/$896

Select

TOPBP1 Antibody LS-C341868

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

TOPBP1 Antibody LS-C772933

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

TOPBP1 Antibody (aa1114-1142) LS-C325868

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (aa1114-1142) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

TOPBP1 Antibody (aa1114-1142, Biotin) LS-C271966

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (aa1114-1142) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

TOPBP1 Antibody (aa1114-1142, FITC) LS-C271968

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (aa1114-1142) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

TOPBP1 Antibody (aa1114-1142, APC) LS-C271965

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (aa1114-1142) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

TOPBP1 Antibody (aa1114-1142, Azide-free, HRP) LS-C271967

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (aa1114-1142) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

TOPBP1 Antibody (aa1114-1142, PE) LS-C271969

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (aa1114-1142) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

TOPBP1 Antibody LS-C779019

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

TOPBP1 Antibody (phospho-Ser1159) LS-C325866

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (pSer1159) Antibody

Reactivity:

Human

Applications:

DB, ELISA

Format:

Unconjugated

Price:

200 µl/$734

Select

TOPBP1 Antibody (phospho-Ser1159, Biotin) LS-C271960

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (pSer1159) (Biotin) Antibody

Reactivity:

Human

Applications:

DB, ELISA

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

TOPBP1 Antibody (phospho-Ser1159, FITC) LS-C271962

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (pSer1159) (FITC) Antibody

Reactivity:

Human

Applications:

DB, ELISA

Format:

FITC Conjugated

Price:

200 µl/$952

Select

TOPBP1 Antibody (phospho-Ser1159, APC) LS-C271959

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (pSer1159) (APC) Antibody

Reactivity:

Human

Applications:

DB, ELISA

Format:

APC Conjugated

Price:

200 µl/$952

Select

TOPBP1 Antibody (phospho-Ser1159, Azide-free, HRP) LS-C271961

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (pSer1159) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

DB, ELISA

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

TOPBP1 Antibody (phospho-Ser1159, PE) LS-C271963

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (pSer1159) (PE) Antibody

Reactivity:

Human

Applications:

DB, ELISA

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

TOPBP1 Antibody (aa1400-C-term) LS-C287042

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal (aa1400-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

TOPBP1 Antibody LS-C802557

Antibody:

TOPBP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

TOPBP1 Antibody (aa892-1146, clone OTI5C12) LS-C799923

Antibody:

TOPBP1 Mouse anti-Human Monoclonal (aa892-1146) (OTI5C12) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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