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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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LMNA / Lamin A+C Antibody (aa464‑572, clone JOL2) IHC‑plus™ LS‑B2973
Note: This antibody replaces LS-C82330
Lamin A+C antibody LS-B2973 is an unconjugated mouse monoclonal antibody to human Lamin A+C (LMNA). Validated for Flow, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-B2973-50
50 µl
Unavailable

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Product Description

Lamin A+C antibody LS-B2973 is an unconjugated mouse monoclonal antibody to human Lamin A+C (LMNA). Validated for Flow, IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
About LMNA / Lamin A+C
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. P02545 NM_005572 NP_005563.1

LMNA Antibody, 70 kDa lamin Antibody, CDCD1 Antibody, CMD1A Antibody, EMD2 Antibody, FPLD Antibody, IDC Antibody, FPL Antibody, FPLD2 Antibody, Lamin A/C Antibody, Lamin Antibody, LFP Antibody, LMNC Antibody, LMN1 Antibody, LMNL1 Antibody, HGPS Antibody, Prelamin-A/C Antibody, PRO1 Antibody, Lamin A Antibody, Lamin A/C-like 1 Antibody, LGMD1B Antibody, CDDC Antibody, CMT2B1 Antibody, LDP1 Antibody


Specifications

Target
Human LMNA / Lamin A+C
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [JOL2]
Conjugations
Unconjugated
Purification
Tissue culture supernatant
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100)
  • Western blot
  • Immunoprecipitation (1:1)
  • Flow Cytometry
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Recombinant human Lamin A.
Epitope
aa464-572
Specificity
The antibody reacts with both recombinant and native Lamin A and C in humans. It has been shown to bind to an epitope between amino acids 464-572
Usage
Immunohistochemistry: LS-B2973 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2973 was determined to be 1:100.
Presentation
Tissue culture supernatant, 0.2 M Tris/HCl, pH 7.4, 5-10% fetal calf serum. Sourced in TCS.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images

Immunohistochemistry

Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.
Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.

Immunohistochemistry

Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.
Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.

Immunohistochemistry

Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.
Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.

Immunohistochemistry

Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.
Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.

Immunohistochemistry

Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.
Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.

Immunohistochemistry

Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.
Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.

Immunohistochemistry

Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.
Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.

Immunohistochemistry

Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.
Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2973 dilution 1:100.

Requested From: 
Date Requested: 7/19/2018

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