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Catalog Number Size Price
LS-B2005-50 50 µl $440 
LMNA / Lamin A+C Antibody - Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
LMNA / Lamin A+C Antibody - Hela cell nuclear extracts were resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit polyclonal anti-lamin A. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system.
LMNA / Lamin A+C Antibody - Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
LMNA / Lamin A+C Antibody - Hela cell nuclear extracts were resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit polyclonal anti-lamin A. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system.
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PathPlus™ Polyclonal Rabbit anti‑Mouse LMNA / Lamin A+C Antibody (C‑Terminus, IHC, IF, WB) LS‑B2005

PathPlus™ Polyclonal Rabbit anti‑Mouse LMNA / Lamin A+C Antibody (C‑Terminus, IHC, IF, WB) LS‑B2005

Note: This antibody replaces LS-C41258
Antibody:
LMNA / Lamin A+C Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P, IF, WB
Reactivity:
Mouse, Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$440
LS-B2005-50
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
LMNA / Lamin A+C Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P, IF, WB
Reactivity:
Mouse, Human
Format:
Unconjugated, Unmodified

Specifications

Description
Lamin A (LMNA, Lamin A/C) and Lamin B are the two types of lamins found in vertebrates. These proteins make up the matrix of the nuclear lamina that lines the inner nuclear membrane. Lamin A is functionally involved in gene expression, nuclear stability, the maintenance of neural circuit function and nervous system integrity, and chromatin structure. A number of diseases are caused by Lamin A mutations, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Wild-type Lamin A has also been found to be overexpressed in the hippocampus in the later stages of Alzheimer’s disease. In immunohistochemistry, Lamin A has high nuclear membrane positivity in all cell types throughout the body. References: Nat. Rev. Genet. 2006. 7 (12): 940–52, PMID: 17139325; Int J Mol Sci. 2019 Feb; 20(4): 878, PMID: 30781626; Cell Stress. 2018 Sep; 2(9): 219–224, PMID: 31223139
Target
Mouse LMNA / Lamin A+C
Synonyms
LMNA | 70 kDa lamin | CDCD1 | CMD1A | EMD2 | FPLD | IDC | FPL | FPLD2 | Lamin A/C | Lamin | LFP | LMNC | LMN1 | LMNL1 | HGPS | Prelamin-A/C | PRO1 | Lamin A | Lamin A/C-like 1 | LGMD1B | CDDC | CMT2B1 | LDP1
Host
Rabbit
Reactivity
Mouse, Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Recombinant mouse LMNA / Lamin A.
Epitope
C-Terminus
Specificity
Recombinant (partial), C-terminal. The immunogen is taken from isoform C and may not cross-react with isoform A.
Applications
  • IHC
  • IHC - Paraffin (1:50)
  • Immunofluorescence
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistochemistry: LS-B2005 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2005 was determined to be 1:50.
Presentation
Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.
Storage
Store at 4°C or -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About LMNA / Lamin A+C
P02545 NM_005572 NP_005563.1

Validation

LMNA / Lamin A+C Antibody - Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.

LSBio Ratings

PathPlus™ LMNA / Lamin A+C Antibody (C-Terminus) for IHC, IF/Immunofluorescence, WB/Western LS-B2005 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (5)

Publications (2)

Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells. Zhang Y, Wang Z, Magnuson NS. Molecular cancer research : MCR. 2007 5:909-22.

Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. Takezaki S, Yamada M, Kato M, Park MJ, Maruyama K, Yamazaki Y, Chida N, Ohara O, Kobayashi I, Ariga T. Journal of immunology (Baltimore, Md. : 1950). 2012 189:1521-6.

Customer Reviews (0)


Request SDS/MSDS

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Technical.Support@LSBio.com

Requested From: United States
Date Requested: 8/15/2022