Lamin A (LMNA, Lamin A/C) and Lamin B are the two types of lamins found in vertebrates. These proteins make up the matrix of the nuclear lamina that lines the inner nuclear membrane. Lamin A is functionally involved in gene expression, nuclear stability, the maintenance of neural circuit function and nervous system integrity, and chromatin structure. A number of diseases are caused by Lamin A mutations, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Wild-type Lamin A has also been found to be overexpressed in the hippocampus in the later stages of Alzheimer’s disease. In immunohistochemistry, Lamin A has high nuclear membrane positivity in all cell types throughout the body.
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