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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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LMNA / Lamin A+C

lamin A/C

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Gene Name: lamin A/C
Synonyms: LMNA, 70 kDa lamin, CDCD1, CMD1A, EMD2, FPLD, IDC, FPL, FPLD2, Lamin A/C, Lamin, LFP, LMNC, LMN1, LMNL1, HGPS, Prelamin-A/C, PRO1, Lamin A, Lamin A/C-like 1, LGMD1B, CDDC, CMT2B1, LDP1
Target Sequences: NM_005572 NP_005563.1 P02545

Publications (5)

1
Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells. Zhang Y, Wang Z, Magnuson NS. Molecular cancer research : MCR. 2007 5:909-22. [PubMed:17855660] Related Antibodies: LS-B2005.
2
Meiotic chromosome pairing and bouquet formation during Eimeria tenella sporulation. del Cacho E, Pags M, Gallego M, Barbero JL, Monteagudo L, Snchez-Acedo C. International journal for parasitology. 2010 40:453-62. (WB, IHC-Fr; Eimeria tenella) [PubMed:19837073] Related Antibodies: LS-C25073.
3
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. Takezaki S, Yamada M, Kato M, Park MJ, Maruyama K, Yamazaki Y, Chida N, Ohara O, Kobayashi I, Ariga T. Journal of immunology (Baltimore, Md. : 1950). 2012 189:1521-6. [PubMed:22730530] Related Antibodies: LS-B2005.
4
The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis. Lanzicher T, Martinelli V, Puzzi L, Del Favero G, Codan B, Long CS, Mestroni L, Taylor MR, Sbaizero O. Scientific reports. 2015 5:13388. (ICC; Human) [Full Text Article] [PubMed:26323789] [PMC:PMC4555041]
5
AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Lanzicher T, Martinelli V, Long CS, Del Favero G, Puzzi L, Borelli M, Mestroni L, Taylor MR, Sbaizero O. Nucleus (Austin, Tex.). 2015 6:394-407. (ICC; Human) [Full Text Article] [PubMed:26309016] [PMC:PMC4915516]
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Filtered by: None
Target
LMNA / Lamin A+C (143)
Reactivity
Human (138)
Mouse (70)
Rat (66)
Bovine (27)
Chicken (1)
Cynodon dactylon (4)
Dog (15)
Guinea pig (3)
Hamster (4)
Horse (7)
Monkey (6)
Pig (14)
Rabbit (7)
Sheep (3)
Xenopus (3)
Application
IHC (78)
IHC-Fr (10)
IHC-P (28)
WB (139)
Flo (11)
ELISA (29)
ICC (43)
IF (32)
IP (29)
Peptide-ELISA (8)
Host
rabbit (90)
mouse (51)
goat (1)
chicken (1)
Isotype
IgG (55)
IgG1 (16)
IgG1,k (8)
IgG2 (1)
IgG2b (1)
IgG3 (8)
IgG3,k (2)
IgM (1)
IgY (1)
Clonality
monoclonal mc (51)
polyclonal pc (92)
Clone
1073CT3.1.3 (1)
12A-2F5 (5)
131C3 (1)
133A2 (2)
1B7 (1)
2G1 (1)
3F6 (1)
40000000 (1)
4C4 (2)
4E7 (1)
5H8-B4 (1)
JOL2 (3)
JoL3 (1)
JOL4 (2)
JoL5 (1)
Format
AP Conjugated (3)
APC (3)
APC Conjugated (6)
Azide-free (1)
Biotin Conjugated (9)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (8)
HRP Conjugated (7)
Magnetic beads Conjugated (1)
PE Conjugated (6)
Sepharose Conjugated (1)
Unconjugated (93)
Epitope
aa1-422 (10)
aa401-427 (8)
C-Terminus (6)
Internal (3)
N-Terminus (3)
aa598-611 (3)
pSer392 (3)
1-80 aa (2)
330-410 aa (2)
Cleaved (2)
aa249-266 (2)
aa572-646 (2)
pSer22 (2)
150-230 aa, Internal (1)
180-260 aa, Internal (1)
Arg386 (1)
Asp230 (1)
Ser17 (1)
aa1-50 (1)
aa150-200 (1)
aa17-66 (1)
aa181-230 (1)
aa2-51 (1)
aa212-261 (1)
aa319-566 (1)
aa361-410 (1)
aa398-490 (1)
aa400-450 (1)
aa451-468 (1)
aa455-469 (1)
aa464-572 (1)
aa465-498 (1)
aa481-646 (1)
aa550-600 (1)
aa59-572 (1)
pSer458 (1)
Publications
No (141)
Yes (2)
Showing 1-25 of 143 results

LMNA / Lamin A+C Antibody (C-Terminus) IHC-plus™ LS-B2005
Publications (2)
Publications (2)
Rabbit Polyclonal (IgG) to Mouse LMNA / Lamin A+C
Mouse, Human
IF IHC IHC-P WB
Unconjugated
50µl  $425.00
Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Hela cell nuclear extracts were resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit polyclonal anti-lamin A. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system.

LMNA / Lamin A+C Antibody (aa59-572) LS-C186225
Rabbit Polyclonal to Human LMNA / Lamin A+C
Mouse, Human
IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $355.00
IHC of paraffin-embedded H441 Xenograft using Lamin A/C antibody at 1:100 dilution.
Sample (20 ug ). A: HeLa Nucleus. 10% SDS PAGE. LMNA / Lamin A/C antibody diluted at 1:3000.

LMNA / Lamin A+C Antibody (aa249-266) IHC-plus™ LS-B119
Rabbit Polyclonal (IgG) to Human LMNA / Lamin A+C
Rabbit, Mouse, Dog, Rat, Hamster, Pig, Horse, Human, Monkey
IHC IHC-P WB
Unconjugated
50µl  $425.00
Anti-Lamin A/C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Western blot of human Lamin A/C in 15 ugs of HeLa cell lysate using antibody at 1:1000 dilution.

LMNA / Lamin A+C Antibody (aa464-572, clone JOL2) IHC-plus™ LS-B2973
Mouse Monoclonal [clone JOL2] (IgG1) to Human LMNA / Lamin A+C
Human
Flo IHC IHC-P IP WB
Unconjugated
50µl  $425.00
Anti-Lamin A/C antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.

LMNA / Lamin A+C Antibody LS-C25073
Publications (1)
Publications (1)
Mouse Monoclonal (IgG1) to Xenopus LMNA / Lamin A+C
Xenopus, Rat, Mouse, Bovine, Human
IF IHC IHC-Fr WB
Unconjugated
50µg  $620.00

LMNA / Lamin A+C Antibody (clone 133A2) IHC-plus™ LS-B7178
Mouse Monoclonal [clone 133A2] (IgG3) to Human LMNA / Lamin A+C
Mouse, Dog, Bovine, Rat, Human
Flo ICC IHC IHC-Fr IHC-P WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Immunohistochemistry on frozen sections of human colon showing nuclear lamina staining in epithelial and connective tissue cells

LMNA / Lamin A+C Antibody (aa572-646, clone JOL4) LS-C82328
Mouse Monoclonal [clone JOL4] (IgG) to Human LMNA / Lamin A+C
Mouse, Human
IF IHC IHC-Fr IP WB
Unconjugated
1ml  $380.00
Lamin expression in basal cell skin carcinomas. Frozen sections stained with Lamin A antibody [JOL4]

LMNA / Lamin A+C Antibody LS-C203167
Rabbit Monoclonal (IgG) to Human LMNA / Lamin A+C
Flo WB
Unconjugated
40µg 80µl 0.5mg/ml  $245.00; 100µg  $325.00
Western blot of cell lysates using 1 ug/ml Rabbit Anti-Lamin A+C Polyclonal Antibody. The signal was developed with IRDye 800 Conjugated Goat Anti-Rabbit IgG. Predicted Size: Lamin A 71 KD Lamin C 65 KD. Observed Size: Lamin A 71 KD Lamin C 65 KD.
Flow cytometry of HepG2 cells using Lamin A+C Antibody, pAb, Rabbit (shaded histogram). Or with an isotype control antibody (open histogram), followed by R-PE conjugated anti-rabbit IgG.

LMNA / Lamin A+C Antibody (Internal) LS-C352469
Rabbit Polyclonal to Human LMNA / Lamin A+C
Chicken, Rat, Pig, Mouse, Human
ICC IF IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of Lamin A/C staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Lamin A/C staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

LMNA / Lamin A+C Antibody (phospho-Ser458) LS-C179909
Rabbit Polyclonal to Human LMNA / Lamin A+C
Human, Monkey
ICC IHC IHC-Fr WB
Unconjugated
100µl  $395.00
Immunohistochemistry Image

LMNA / Lamin A+C Antibody (C-Terminus, Sepharose) LS-C171858
Rabbit Polyclonal to Human LMNA / Lamin A+C
Mouse, Rat, Human
IHC IP WB
Sepharose Conjugated
100µg  $325.00
 This image was taken for the unconjugated form of this product. Other forms have not been tested.
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

LMNA / Lamin A+C Antibody (aa181-230) IHC-plus™ LS-B7728
Rabbit Polyclonal (IgG) to Human LMNA / Lamin A+C
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-LMNA / Lamin A/C antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Western blot of extracts from HeLa cells, treated with Etoposide 25 uM 60', using Lamin A (Cleaved-Asp230) Antibody. The lane on the right is treated with the synthesized peptide.

LMNA / Lamin A+C Antibody (Internal) LS-C352468
Rabbit Polyclonal to Human LMNA / Lamin A+C
Mouse, Bovine, Rat, Pig, Human, Monkey
ICC IF IHC IHC-P IP WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of Lamin A/C staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Lamin A/C staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

LMNA / Lamin A+C Antibody (phospho-Ser392) LS-C354018
Rabbit Polyclonal to Human LMNA / Lamin A+C
Mouse, Bovine, Rat, Pig, Human, Monkey
ICC IF IHC IHC-P IP WB
Unconjugated
100µl 1mg/ml  $265.00
Immunohistochemical analysis of Lamin A/C (pS392) staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of Lamin A/C (pS392) staining in SHSY5Y cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

LMNA / Lamin A+C Antibody (aa212-261) IHC-plus™ LS-B7729
Rabbit Polyclonal (IgG) to Human LMNA / Lamin A+C
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-LMNA / Lamin A/C antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Anti-LMNA / Lamin A/C antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.

LMNA / Lamin A+C Antibody (aa481-646) LS-C357473
Rabbit Polyclonal to Human LMNA / Lamin A+C
Mouse, Rat, Human
ICC IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $325.00
Lamin A antibody IHC-paraffin: Mouse Intestine Tissue.
Lamin A antibody IHC-paraffin: Human Mammary Cancer Tissue.

LMNA / Lamin A+C Antibody (aa598-611) LS-C25076
Mouse Monoclonal (IgG3,k) to Human LMNA / Lamin A+C
Mouse, Dog, Bovine, Rat, Human
Flo ICC IHC IHC-Fr WB
Unconjugated
100µg  $560.00

LMNA / Lamin A+C Antibody (aa598-611, clone 133A2) LS-C82250
Mouse Monoclonal [clone 133A2] (IgG3,k) to Human LMNA / Lamin A+C
Human
Flo ICC IHC WB
Unconjugated
50µl  $380.00
Immunostaining reaction of lamin A antibody with human epidermis

LMNA / Lamin A+C Antibody (clone 131C3) LS-C146766
Mouse Monoclonal [clone 131C3] (IgG1) to Human LMNA / Lamin A+C
Mouse, Dog, Sheep, Bovine, Rat, Hamster, Human
Flo ICC IHC IHC-Fr WB
Unconjugated
0.1mg  $375.00
Immunohistochemistry on frozen tissue section of human colon showing nuclear lamina staining in epithelial and connective tissue cells
Immunoblotting of 131C3 recognizing Nuclear Lamins A and C in human fibroblast lysate

LMNA / Lamin A+C Antibody (phospho-Ser392) LS-C416438
Rabbit Polyclonal to Human LMNA / Lamin A+C
Mouse, Rat, Human
ICC IF IHC WB
Unconjugated
100µg 1mg/ml  $305.00
Western blot of Lamin A/C phosphorylation expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

LMNA / Lamin A+C Antibody LS-C417355
Rabbit Polyclonal to Human LMNA / Lamin A+C
Mouse, Rat, Human
ICC IF IHC WB
Unconjugated
100µg 1mg/ml  $305.00
Western blot of Lamin A/C expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

LMNA / Lamin A+C Antibody (aa455-469) LS-C388836
Rabbit Polyclonal (IgG) to Human LMNA / Lamin A+C
Rabbit, Mouse, Guinea pig, Sheep, Bovine, Rat, Hamster, Pig, Horse, Human
ICC IHC IHC-P WB
Unconjugated
100µg  $435.00
IHC-P: Lamin A/C antibody testing of human lung cancer tissue
IHC-P: Lamin A/C antibody testing of mouse intestine tissue

LMNA / Lamin A+C Antibody (phospho-Ser392) LS-C199188
Rabbit Polyclonal (IgG) to Human LMNA / Lamin A+C
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Lamin A/C (Phospho-Ser392) Antibody. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of HeLa cells, using Lamin A/C (Phospho-Ser392) Antibody. The picture on the right is blocked with the phospho peptide.

LMNA / Lamin A+C Antibody (330-410 aa) LS-C381477
Rabbit Polyclonal (IgG) to Human LMNA / Lamin A+C
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
100µl 1mg/ml  $265.00

LMNA / Lamin A+C Antibody (aa361-410) LS-C117663
Rabbit Polyclonal (IgG) to Human LMNA / Lamin A+C
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Lamin A/C Antibody. The picture on the right is blocked with the synthesized peptide.
Immunofluorescence analysis of HeLa cells, using Lamin A/C Antibody. The picture on the right is blocked with the synthesized peptide.
Showing 1-25 of 143 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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