IRF3

interferon regulatory factor 3

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

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Products

Antibodies (112)

Proteins (14)

ELISA Kits (12)

Type

Cell-Based (1)

Custom (4)

Over-Expression Lysate (6)

Primary (112)

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Sandwich (7)

Target

IRF3 (138)

Reactivity

Human (92)

Mouse (47)

Rat (20)

African green monkey (1)

Bat (3)

Bovine (5)

Chicken (1)

Chimpanzee (3)

Dog (3)

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Goat (1)

Guinea pig (3)

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IHC (41)

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ELISA (34)

ICC (8)

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rabbit (90)

mouse (21)

goat (1)

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Antibodies to Coronavirus-Associated Targets (112)

Coronavirus Antibodies Proteins cDNAs (126)

Coronavirus Detection (12)

ELISA Kits for Associated Targets (12)

IHCPlus (5)

SARS-CoV-2 Associated Proteins (14)

Isotype

IgG (62)

IgG1 (9)

IgG1,k (2)

IgG2a (4)

IgG2a,k (1)

IgG2b (4)

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monoclonal mc (20)

polyclonal pc (92)

Clone

1522CT766.58.24 (1)

3C8 (1)

3F10 (2)

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OTI2G3 (2)

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Epitope

aa1-360 (8)

aa1-406 (8)

aa46-72 (7)

aa27-169 (6)

aa351-400 (5)

pSer385 (5)

aa108-166 (3)

pSer396 (3)

320-400 aa (2)

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aa100-150 (2)

pSer386 (2)

330-410 aa (1)

340-420 aa (1)

Ala379 (1)

Pro173 (1)

Val391 (1)

aa206-427 (1)

aa275-325 (1)

aa352-401 (1)

aa362-411 (1)

aa375-419 (1)

aa409-427 (1)

aa78-108 (1)

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No (138)

Sample Type

Adherent Cell Cultures (1)

Cell Lysates (2)

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Serum (5)

Tissue Homogenates (5)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST (2)

His-T7 (2)

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Species

Human (9)

Mouse (2)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (5)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (1)

Select

IHC-plus™ IRF3 Antibody LS-B182

(4.0) Rating

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

ELISA, ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

Select

IRF3 Antibody (phospho-Ser385) LS-C357142

Antibody:

IRF3 Rabbit anti-Human Polyclonal (pSer385) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$391

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Human IRF3 Protein (Recombinant GST) (Full Length) - LS-G29083

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human IRF3 (Sandwich ELISA) ELISA Kit - LS-F4800

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

Select

IRF3 Antibody (phospho-Ser385) LS-C199138

Antibody:

IRF3 Rabbit anti-Human Polyclonal (pSer385) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

IRF3 Antibody (clone 1522CT766.58.24) LS-C392581

Antibody:

IRF3 Mouse anti-Human Monoclonal (1522CT766.58.24) Antibody

Reactivity:

Human, African green monkey

Applications:

Flo, IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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IRF3 Antibody (320-400 aa) LS-C381472

Antibody:

IRF3 Rabbit anti-Human Polyclonal (320-400 aa) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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Mouse IRF3 (Sandwich ELISA) ELISA Kit - LS-F6088

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$715

Select

IRF3 Antibody (clone OTI4D4) LS-C114575

Antibody:

IRF3 Mouse anti-Human Monoclonal (OTI4D4) Antibody

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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IRF3 Antibody (clone OTI4D4, Carrier-free) LS-C784298

Antibody:

IRF3 Mouse anti-Human Monoclonal (Carrier-free) (OTI4D4) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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IHC-plus™ IRF3 Antibody LS-B135

(4.0) Rating

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ IRF3 Antibody (aa275-325) LS-B11648

(4.0) Rating

Antibody:

IRF3 Rabbit anti-Mouse Polyclonal (aa275-325) Antibody

Reactivity:

Mouse

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$485

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IRF3 Antibody (clone 3C8) LS-C197546

Antibody:

IRF3 Mouse anti-Human Monoclonal (3C8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$423

Select

IHC-plus™ IRF3 Antibody LS-B2529

(4.0) Rating

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

Mouse IRF3 Protein (Recombinant His-T7) (aa1-406) - LS-G14032

Source:

E. coli

Tag:

His-T7

Molecular Weight:

49.2 kDa

Price:

10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198

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IRF3 Antibody (aa108-166, clone 3F10) LS-C45030

Antibody:

IRF3 Mouse anti-Human Monoclonal (aa108-166) (3F10) Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$505

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IRF3 Antibody (aa46-72) LS-C322272

Antibody:

IRF3 Rabbit anti-Mouse Polyclonal (aa46-72) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

IRF3 Antibody (clone IRF35I218) LS-C342311

Antibody:

IRF3 Mouse anti-Human Monoclonal (IRF35I218) Antibody

Reactivity:

Human

Applications:

DB, Flo, ICC, IF, IP, WB

Format:

Unconjugated

Price:

100 µg/$486

Select

IRF3 Antibody (phospho-Ser396) LS-C199140

Antibody:

IRF3 Rabbit anti-Human Polyclonal (pSer396) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

IRF3 Antibody LS-C499144

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

IRF3 Antibody (clone OTI2G3) LS-C114617

Antibody:

IRF3 Mouse anti-Human Monoclonal (OTI2G3) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

Select

IRF3 Antibody (C-Terminus) LS-C413182

Antibody:

IRF3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Bovine, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$341

Select

IRF3 Antibody (C-Terminus) LS-C368606

Antibody:

IRF3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Bovine, Pig, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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IRF3 Antibody LS-C666490

Antibody:

IRF3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

IRF3 Antibody (phospho-Ser385) LS-C801186

Antibody:

IRF3 Rabbit anti-Human Polyclonal (pSer385) Antibody

Reactivity:

Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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