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Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
Gene Name: | interleukin 11 |
Family/Subfamily: | Hormone , not assigned-Hormone |
Synonyms: | IL11, AGIF, Adipogenesis inhibitory factor, IL-11, Interleukin-11, Interleukin 11 |
Target Sequences: | NM_000641 NP_000632.1 P20809 |
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