IL11 Protein LS-G27182 is Recombinant Human IL11 in Hamster-Chinese It is biologically active and is low in endotoxin Less than 0.2 EU/µg protein (determined by LAL method)..
Predicted Molecular Weight
~23 kDa (SDS-PAGE)
Interleukin-11 is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1a-stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive mouse plasmacytoma cell line T11. IL-11 has multiple effects on both hematopoietic and non-hematopoietic cells. Many of the biological effects described for IL-11 overlap with those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell-dependent development of specific immunoglobulin-secreting B cells.
Greater than 95% by SDS-PAGE and HPLC
ED50 <5 ng/ml, measured in a proliferation assay using T11 cells.
Less than 0.2 EU/µg protein (determined by LAL method).
Lyophilized from PBS
Reconstitute in sterile ddH20 or PBS at 100 ug/ml.
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 1 week or at -20°c for up to 2 months.
For research use only.