Human ER Alpha / Estrogen Receptor

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

AER304

Unconjugated

Purified

Unmodified

AER304 is a mouse monoclonal IgG1 antibody derived by fusion of Sp2/0-Ag14 mouse myeloma cells with splenocytes from a BALB/c mouse, immunized with estrogen receptor protein purified from calf uterus.

The antibody AER304 is directed against estrogen receptor alpha (ER alpha ) and recognizes amino acids residues 120 - 170, an epitope located in the B domain of ER alpha.

• ICC
• Western blot
• Immunoprecipitation

Estrogen receptor (ER) is a hormone binding molecule, which belongs to the nuclear hormone family of intracellular receptors. Estrogen receptors exist as alpha and beta forms encoded by separate genes ESR1 and ESR2. ER alpha and ER beta share a high degree of sequence homology and are activated by the hormone 17 beta -estradiol and related compounds, including phytoestrogens and xenoestrogens. Both ER alpha and ER beta function as transcription factors which mediate many of the biological effects of estradiol at the level of gene regulation. Both receptors and are involved in the normal development and function of numerous tissues. Studies also suggest that ER's may be involved in a range of pathological conditions including cancers, neurodegenerative diseases and cardiovascular disease.

PBS, 50% glycerol, 0.2% BSA, 0.02% sodium azide

Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P03372 NCBI: NM_000125 NP_000116.2