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ER Alpha / Estrogen Receptor

estrogen receptor 1

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.

Gene Name: estrogen receptor 1
Family/Subfamily: NHR , NR3 Steroid receptor
Synonyms: ESR1, Era, ERalpha, Estrogen receptor, ER-alpha, Estrogen receptor 1, NR3A1, ER, ESR, ESRA, Estrogen receptor alpha
Target Sequences: NM_000125 NP_000116.2 P03372

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Antibodies (332)
Primary (332)
ER Alpha / Estrogen Receptor (332)
Human (300)
Mouse (121)
Rat (70)
Bovine (15)
Chicken (3)
Chimpanzee (6)
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rabbit (247)
mouse (84)
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monoclonal mc (91)
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107 (1)
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415CT16.3.2.1 (6)
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aa283-312 (8)
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pSer102 (2)
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250-330 aa (1)
Amino Acid: 130-339 (1)
Amino Acid: 301-595 (1)
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SLQKYYITGEAEGFPATVc (1)
Tyr537 (1)
aa1-190 (1)
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aa1-50 (1)
aa302-595 (1)
aa410-592 (1)
aa425-595 (1)
aa501-550 (1)
aa525-575 (1)
aa582-595 (1)
aa71-120 (1)
aa81-130 (1)
aa91-140 (1)
p104 (1)
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p167 (1)
p537 (1)
pS104 (1)
No (331)
Yes (1)
ER Alpha / Estrogen Receptor Antibody - Anti-Estrogen Receptor antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Cancer Pathology
Cancer
ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ICC, IHC-P
Unconjugated
50 µl/$440
ER Alpha / Estrogen Receptor Antibody - Formalin-fixed, paraffin-embedded human breast carcinoma stained with peroxidase-conjugate and AEC chromogen. Note nuclear staining of tumor cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$340
ER Alpha / Estrogen Receptor Antibody - Formalin-fixed, paraffin-embedded human breast carcinoma stained with peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells.
Select
ER Alpha / Estrogen Receptor Mouse anti-Human Monoclonal (1D5 + 6F11) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$365
Select
ER Alpha / Estrogen Receptor Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat
ELISA, WB
Unconjugated
100 µg/$331
ER Alpha / Estrogen Receptor Antibody - Human Breast, Carcinoma: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
ER Alpha / Estrogen Receptor Mouse anti-Human Monoclonal (1D5) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
250 µl/$485
ER Alpha / Estrogen Receptor Antibody - Formalin-fixed, paraffin-embedded human breast carcinoma stained with peroxidase-conjugate and DAB chromogen. Note intense nuclear staining of tumor cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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ER Alpha / Estrogen Receptor Mouse anti-Human Monoclonal (Azide-free) (1D5) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated, Azide-free
100 µl/$1,192
ER Alpha / Estrogen Receptor Antibody - Anti-ER Alpha / Estrogen Receptor antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (aa53-301) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$440
ER Alpha / Estrogen Receptor Antibody - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
Select
ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (pSer167) Antibody
IF, IHC, WB
Unconjugated
50 µl/$306; 100 µl/$381; 200 µl/$489
ER Alpha / Estrogen Receptor Antibody - Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
ER Alpha / Estrogen Receptor Rabbit anti-Human Monoclonal (SP1) Antibody
Hamster, Human
IHC-P, WB
Unconjugated
0.05 ml/$460
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ER Alpha / Estrogen Receptor Mouse anti-Bovine Monoclonal (Biotin) (AER314) Antibody
Rabbit, Mouse, Bovine, Rat, Human
GS, IP
Biotin Conjugated
100 µl/$373; 500 µl/$699; 1000 µl/$881
ER Alpha / Estrogen Receptor Antibody - Western blot of Phospho-ERalpha (S106) antibody
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ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (40-120 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
ER Alpha / Estrogen Receptor Antibody - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
Select
ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (pSer118) Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$253; 50 µl/$306; 100 µl/$381; 200 µl/$489
ER Alpha / Estrogen Receptor Antibody - Formalin-fixed, paraffin-embedded human breast carcinoma stained with peroxidase-conjugate and AEC chromogen. Note nuclear staining of tumor cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal Antibody
Hamster, Human
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$383; 500 µl/$787; 1 ml/$980
Select
ER Alpha / Estrogen Receptor Mouse anti-Bovine Monoclonal (AER314) Antibody
Mouse, Human
IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$421
ER Alpha / Estrogen Receptor Antibody - ESR1/ER Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human breast carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (aa246-273) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$381
ER Alpha / Estrogen Receptor Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Estrogen Receptor-alpha Antibody. The picture on the right is blocked with the synthesized peptide.
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ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (aa501-550) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$318; 100 µl/$378
Select
ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (aa1-21) Antibody
Rabbit, Mouse, Rat, Hamster, Horse, Human, Monkey
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$910
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ER Alpha / Estrogen Receptor Mouse anti-Human Monoclonal (AER311) Antibody
Mouse, Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$421
ER Alpha / Estrogen Receptor Antibody - Formalin-fixed, paraffin-embedded human breast carcinoma stained with peroxidase-conjugate and DAB chromogen. Note intense nuclear staining of tumor cells.
Select
ER Alpha / Estrogen Receptor Mouse anti-Human Monoclonal (6F11) Antibody
Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
0.1 ml/$418
ER Alpha / Estrogen Receptor Antibody - Detection of Human Estrogen Receptor alpha by Immunohistochemistry. Sample: FFPE section of human breast. Antibody: Affinity purified rabbit anti-ER alpha used at a dilution of 1:100. Detection: DAB.
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ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (aa550-C-term) Antibody
Human
IF, IHC
Unconjugated
100 µl/$500
ER Alpha / Estrogen Receptor Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Estrogen Receptor-alpha (Phospho-Ser118) Antibody. The picture on the right is blocked with the phospho peptide.
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ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (pSer118) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$318; 100 µl/$378
ER Alpha / Estrogen Receptor Antibody - Immunohistochemical analysis of Estrogen Receptor alpha staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$245; 100 µl/$289; 200 µl/$341
ER Alpha / Estrogen Receptor Antibody - Western blot of ERalpha antibody
Select
ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (470-550 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
Select
ER Alpha / Estrogen Receptor Mouse anti-Human Monoclonal (aa582-595) (C0542) Antibody
Human
GS, ICC, IHC, IP, WB
Unconjugated
50 µg/$551; 200 µg/$859
ER Alpha / Estrogen Receptor Antibody - Anti-Estrogen Receptor antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
ER Alpha / Estrogen Receptor Rabbit anti-Human Polyclonal (aa91-140) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).