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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CLCN1 / CLC‑1 Antibody (C‑Terminus) LS‑C6116
CLC-1 antibody LS-C6116 is an unconjugated rabbit polyclonal antibody to rat CLC-1 (CLCN1). Validated for ELISA and WB.
Antibody
Catalog
Size
Price
LS-C6116-100
100 µl
$725

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Product Description

CLC-1 antibody LS-C6116 is an unconjugated rabbit polyclonal antibody to rat CLC-1 (CLCN1). Validated for ELISA and WB.

Specifications

Target
Rat CLCN1 / CLC-1
Synonyms
CLCN1, Chloride channel protein 1, ClC-1, SMCC1, Chloride channel 1, CLC1
Host
Rabbit
Reactivity
Rat (tested or 100% immunogen sequence identity)
Predicted
Human, Mouse, Dog (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Antiserum
Modifications
Unmodified
Applications
  • Western blot (1:1000 - 1:5000)
  • ELISA (1:10000 - 1:50000)
Immunogen
CLCN1 / CLC-1 antibody was raised against an 18 AA Peptide sequence near the C-terminus of rat CLC-1 (1). The peptide was coupled to KLH.
Epitope
C-Terminus
Specificity
The 18 AA rat control peptide 100% conserved in mouse, rat and human CLC-1. No significant sequence homology is detected with other CLCs or other proteins. Because of the low MW (<3kD) of the control peptide, it is not recommended for Western. The control peptide is available to confirm specificity of antibodies.
Usage
Suitable for use in ELISA, Western Blot. Western Blot: 1:1000-1:5000 for neat serum and 1-10 ug/ml for affinity pure antibody using ECL. ELISA:1:10000-1:50000 for neat serum and 0.5-1 ug/ml for affinity purified. Control peptide can be used to coat ELISA plates at 1 ug/ml.
Presentation
PBS, 0.05% Sodium Azide
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About CLCN1 / CLC-1
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). P35523 NM_000083 NP_000074.2


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Requested From: United States
Date Requested: 10/20/2018

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