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CLCN1 / CLC-1

chloride channel, voltage-sensitive 1

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants.

Gene Name: chloride channel, voltage-sensitive 1
Family/Subfamily: Ion Channel , Chloride channel - CLC
Synonyms: CLCN1, Chloride channel protein 1, ClC-1, SMCC1, Chloride channel 1, CLC1
Target Sequences: NM_000083 NP_000074.2 P35523

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Products
Antibodies (18)
Primary (18)
CLCN1 / CLC-1 (18)
Human (15)
Mouse (5)
Rat (8)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
IHC (2)
WB (13)
Flo (1)
ELISA (9)
IF (1)
Peptide-ELISA (1)
rabbit (18)
Ig (1)
IgG (8)
polyclonal pc (18)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (12)
aa771-820 (4)
C-Terminus (2)
N-Terminus (2)
No (18)
CLCN1 / CLC-1 Antibody - All lanes: Anti-CLCN1 Antibody (N-Term) at 1:2000 dilution Lane 1: Human skeletal muslce lysate Lane 2: Mouse skeletal muscle lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 109 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, Flo, WB
Unconjugated
200 µl/$393
CLCN1 / CLC-1 Antibody - Western blot analysis of extracts of various cell lines.
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
CLCN1 / CLC-1 Antibody - Immunofluorescent analysis of HepG2 cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
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CLCN1 / CLC-1 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, WB
Unconjugated
100 µg/$832
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
CLCN1 / CLC-1 Antibody - Western blot analysis of CLCN1 using K562 whole cells lysates
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CLCN1 / CLC-1 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, WB
Unconjugated
100 µl/$801
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µg/$331
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$431
CLCN1 / CLC-1 Antibody - Western blot analysis of CLCN1 expression in HeLa (A); NIH3T3 (B); H9C2 (C) whole cell lysates.
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CLCN1 / CLC-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$299
CLCN1 / CLC-1 Antibody - CLCN1 / CLC-1 antibody Western blot of Rat Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLCN1 / CLC-1 Rabbit anti-Rat Polyclonal (aa771-820) Antibody
Mouse, Rat
WB
Unconjugated
100 µl/$424
CLCN1 / CLC-1 Antibody - CLCN1 / CLC-1 antibody Western blot of Rat Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLCN1 / CLC-1 Rabbit anti-Rat Polyclonal (aa771-820) (HRP) Antibody
Dog, Guinea pig, Rat, Horse, Gibbon, Human
WB
HRP Conjugated
100 µl/$469
CLCN1 / CLC-1 Antibody - CLCN1 / CLC-1 antibody Western blot of Rat Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CLCN1 / CLC-1 Rabbit anti-Rat Polyclonal (aa771-820) (Biotin) Antibody
Dog, Guinea pig, Rat, Horse, Gibbon, Human
WB
Biotin Conjugated
100 µl/$469
CLCN1 / CLC-1 Antibody - CLCN1 / CLC-1 antibody Western blot of Rat Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
CLCN1 / CLC-1 Rabbit anti-Rat Polyclonal (aa771-820) (FITC) Antibody
Dog, Guinea pig, Rat, Horse, Gibbon, Human
WB
FITC Conjugated
100 µl/$469
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).