CD300A antibody LS-C187548 is an RPE-conjugated mouse monoclonal antibody to human CD300A. Validated for Flow.
(tested or 100% immunogen sequence identity)
CD300A antibody was raised against polyclonal population of NK cells.
Recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kD transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, 0.09% sodium azide, 1% BSA, 5% sucrose
100 tst Reconstitute with 1ml distilled water.
Store at 4°C. Do not freeze. Protect from light.