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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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CD300A Antibody (clone P192) LS-C187546

Human peripheral blood monocytes stained with Mouse anti-Human CD300a followed by Rabbit F(ab')2 anti-Mouse IgG:FITC

CD300A Antibody (clone P192) LS-C187546

Antibody:
Mouse Monoclonal to Human CD300A
Application:
Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$445 
LS-C187546-0.2
Toll Free North America
866-819-4732

Overview

Antibody:
Mouse Monoclonal to Human CD300A
Application:
Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
CD300A antibody LS-C187546 is an unconjugated mouse monoclonal antibody to human CD300A. Validated for Flow.

Target
Human CD300A
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Clone
P192
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Flow Cytometry
Immunogen
CD300A antibody was raised against polyclonal population of NK cells.
Specificity
Recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kD transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.
Presentation
PBS, 0.09% Sodium Azide
Storage
Store at 4°C to 20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CD300A
Q9UGN4 NM_007261 CAB52291.1

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Requested From: United States
Date Requested: 6/26/2019
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