PD-L1 antibody LS-C743953 is an unconjugated rabbit monoclonal antibody to human PD-L1 (CD274 / B7-H1). Validated for IHC.
Human CD274 / B7-H1 / PD-L1
(tested or 100% immunogen sequence identity)
KLH-conjugated linear peptide from human PD-L1
Unmasking with antigen retrieval Programmed cell death ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1) is a type 1 transmembrane protein involved in the regulation of cellular and humoral immune responses. The interaction of PD-L1 with its receptor PD-1 provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy, tissue allograft, autoimmune disease and malignant transformation. The binding of PD-L1 to PD-1 induces apoptosis or exhaustion in activated T cells, and blockade of this interaction has been shown to enhance the antitumor activity of T cells. PD-L1 is frequently over expressed in placenta, and many human tumours such as melanoma, diffuse large B-cell lymphoma, and carcinomas of the lung, bladder, breast, kidney and colon. Human CD274, PD-L1.
PBS, pH 7.3, 0.09% Sodium Azide
About CD274 / B7-H1 / PD-L1