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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CD274 / B7-H1 / PD-L1 Antibody LS-C743953

Antibody

CD274 / B7-H1 / PD-L1 Antibody LS-C743953

Antibody:
Rabbit Monoclonal to Human CD274 / B7-H1 / PD-L1
Application:
IHC-P, IHC-Fr
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$475 
LS-C743953-0.1
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Monoclonal to Human CD274 / B7-H1 / PD-L1
Application:
IHC-P, IHC-Fr
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
PD-L1 antibody LS-C743953 is an unconjugated rabbit monoclonal antibody to human PD-L1 (CD274 / B7-H1). Validated for IHC.

Target
Human CD274 / B7-H1 / PD-L1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Monoclonal
Conjugations
Unconjugated
Modifications
Unmodified
Applications
  • IHC - Paraffin (1:50 - 1:100)
  • IHC - Frozen (1:50 - 1:100)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
KLH-conjugated linear peptide from human PD-L1
Usage
Unmasking with antigen retrieval Programmed cell death ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1) is a type 1 transmembrane protein involved in the regulation of cellular and humoral immune responses. The interaction of PD-L1 with its receptor PD-1 provides both stimulatory and inhibitory signals in regulating T cell activation and tolerance during pregnancy, tissue allograft, autoimmune disease and malignant transformation. The binding of PD-L1 to PD-1 induces apoptosis or exhaustion in activated T cells, and blockade of this interaction has been shown to enhance the antitumor activity of T cells. PD-L1 is frequently over expressed in placenta, and many human tumours such as melanoma, diffuse large B-cell lymphoma, and carcinomas of the lung, bladder, breast, kidney and colon. Human CD274, PD-L1.
Presentation
PBS, pH 7.3, 0.09% Sodium Azide
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CD274 / B7-H1 / PD-L1
Q9NZQ7 NM_014143 NP_054862.1

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Reactivity: Human
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Requested From: United States
Date Requested: 7/18/2019
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