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Anti-ZAP70 Antibody (aa282-307) LS-C11129

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Wt. Vol. Conc. Price
200 µg - - $485
Inquire for larger quantities

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Mouse Monoclonal (IgG1) to Human ZAP70
Human, Mouse
ICC, Western blot, Immunoprecipitation
Unconjugated

Details

Human ZAP70
Mouse
Human, Mouse (tested or 100% immunogen sequence identity)
IgG1 Monoclonal
Protein G purified

Applications

ICC, Western blot, Immunoprecipitation

Specificity and Use

ZAP70 antibody was raised against kLH conjugated synthetic peptide between the second SH2 domain and preceding the kinase domain corresponding to residues 282-307 of human Zap-70.
aa282-307
Recognizes human Zap-70, Mr ~70kD. Species cross-reactivity: Mouse.
Suitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation. Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system. Immunoprecipitation: 4 ug immunoprecipitates Zap-70 from 500 ug of Jurkat RIPA lysate.

Packaging

0.1 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 0.05% sodium azide, 30% glycerol.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About ZAP70

P43403 NM_207519 P43403

ZAP70 Antibody, 70 kDa zeta-associated protein Antibody, SRK Antibody, STCD Antibody, STD Antibody, Syk-related tyrosine kinase Antibody, Tyrosine-protein kinase ZAP-70 Antibody, TZK Antibody, ZAP-70 Antibody, Zeta-associated protein 70 Antibody

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane.

Requested From: United States
Date Requested: 9/27/2016

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