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Anti-VTCN1 / B7-H4 Antibody (clone MIH43, RPE) LS-C58214

Note: This antibody replaces LS-C126946

Ordering

Wt. Vol. Conc. Price
- 100 tst 0.1 mg/ml $345
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular VTCN1 / B7-H4 Antibodies

Anti-VTCN1 / B7-H4 Antibody (aa138-149) LS-C55682
Goat Polyclonal to Human VTCN1 / B7-H4
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit
Western blot, ELISA
Unconjugated
Western blot Image
Anti-VTCN1 / B7-H4 Antibody (clone H74, Biotin) LS-C106476
Mouse Monoclonal [clone H74] (IgG1,k) to Human VTCN1 / B7-H4
Human
Flow Cytometry
Biotin Conjugated
Flow Cytometry Image
Anti-VTCN1 / B7-H4 Antibody (clone H74) IHC-plus™ LS-B4055
Mouse Monoclonal [clone H74] (IgG1,k) to Human VTCN1 / B7-H4
Human
IHC - Paraffin, Flow Cytometry
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone MIH43] (IgG1) to Human VTCN1 / B7-H4
Human
IHC - Paraffin, IHC - Frozen, Flow Cytometry (applications tested for the base form of this product only)
RPE Conjugated

Details

Human VTCN1 / B7-H4
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MIH43]
R. Phycoerythrin. Also available Unconjugated or conjugated with FITC.
Affinity purified
Unmodified

Applications

  • IHC - Paraffin
  • IHC - Frozen
  • Flow Cytometry (1:1)
  • (applications tested for the base form of this product only)

Specificity and Use

VTCN1 / B7-H4 antibody was raised against human B7-H4.
Recognizes human B7-H4, also known as B7x, a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 could be a useful prognostic marker in Renal Cell Carcinoma (RCC).
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request.

Packaging

Lyophilized, PBS, pH 7.4, 0.09% sodium azide, 1% BSA.
100 tst Distilled Water.
+4°C, avoid freezing
For research use only.

About VTCN1 / B7-H4

Q7Z7D3 NM_024626 NP_078902.2

VTCN1 Antibody, B7 superfamily member 1 Antibody, B7 Superfamily, member 1 Antibody, B7h.5 Antibody, B7S1 Antibody, B7H4 Antibody, PRO1291 Antibody, VCTN1 Antibody, RP11-229A19.4 Antibody, B7 family member, H4 Antibody, B7-H4 Antibody, B7X Antibody, Protein B7S1 Antibody

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Flow Cytometry

Flow Cytometry
Staining of human peripheral blood monocytes with MOUSE ANTI HUMAN B7-H4: RPE. This image was taken for the unconjugated form of this product. Other forms have not been tested.
 

Requested From: United States
Date Requested: 12/4/2016

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