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Anti-VTCN1 / B7-H4 Antibody (clone MIH43) LS-C58213

Note: This antibody replaces LS-C58211, LS-C121400, LS-C121399


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $275
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Alternate Forms of this Antibody

LS-C58212 FITC Conjugated
LS-C58214 RPE Conjugated

Most Popular VTCN1 / B7-H4 Antibodies

Anti-VTCN1 / B7-H4 Antibody (aa138-149) LS-C55682
Goat Polyclonal to Human VTCN1 / B7-H4
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Rabbit
Western blot, ELISA
Western blot Image
Anti-VTCN1 / B7-H4 Antibody (clone H74, Biotin) LS-C106476
Mouse Monoclonal [clone H74] (IgG1,k) to Human VTCN1 / B7-H4
Flow Cytometry
Biotin Conjugated
Flow Cytometry Image
Anti-VTCN1 / B7-H4 Antibody (clone H74) IHC-plus™ LS-B4055
Mouse Monoclonal [clone H74] (IgG1,k) to Human VTCN1 / B7-H4
IHC - Paraffin, Flow Cytometry
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone MIH43] (IgG1) to Human VTCN1 / B7-H4
IHC - Paraffin, IHC - Frozen, Flow Cytometry (applications tested for the base form of this product only)


Human VTCN1 / B7-H4
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MIH43]
Affinity purified


  • IHC - Paraffin (1:50)
  • IHC - Frozen
  • Flow Cytometry (1:25 - 1:50)
  • (applications tested for the base form of this product only)

Specificity and Use

VTCN1 / B7-H4 antibody was raised against human B7-H4.
Recognizes human B7-H4, also known as B7x, a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 could be a useful prognostic marker in Renal Cell Carcinoma (RCC).
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100ul. Immunohistochemistry: This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Histology Positive Control Tissue: Tonsil, breast carcinoma.


PBS, 0.09% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

About VTCN1 / B7-H4

Q7Z7D3 NM_024626 NP_078902.2

VTCN1 Antibody, B7 superfamily member 1 Antibody, B7 Superfamily, member 1 Antibody, B7h.5 Antibody, B7S1 Antibody, B7H4 Antibody, PRO1291 Antibody, VCTN1 Antibody, RP11-229A19.4 Antibody, B7 family member, H4 Antibody, B7-H4 Antibody, B7X Antibody, Protein B7S1 Antibody

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

Requested From: United States
Date Requested: 10/25/2016

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