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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TP53BP1 / 53BP1 Antibody (Ser25/Ser29) LS‑C131177
Antibody
53BP1 antibody LS-C131177 is an unconjugated rabbit polyclonal antibody to 53BP1 (TP53BP1) from human and monkey. Validated for WB.
Catalog
Size
Price
LS-C131177-100
100 µl
Unavailable

Popular TP53BP1 / 53BP1 Products

Anti-TP53BP1 / 53BP1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B315 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Applications: IHC, IHC - Paraffin, ICC, Western blot
Anti-TP53BP1 / 53BP1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1714 concentration 5 ug/ml.
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Anti-TP53BP1 / 53BP1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6175 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Detection of Human and Mouse Phospho 53BP1 (S25) by Immunohistochemistry. Sample: FFPE sections of human stomach carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti- Phospho 53bp1 (S25) used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
Species: Human, Mouse, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry, Proximity Ligation Assay
Antibody
Species: Human, Mouse, Rat
Applications: IHC, Immunofluorescence, Peptide Enzyme-Linked Immunosorbent Assay

Product Description

53BP1 antibody LS-C131177 is an unconjugated rabbit polyclonal antibody to 53BP1 (TP53BP1) from human and monkey. Validated for WB.
About TP53BP1 / 53BP1
Tumor protein p53 binding protein 1 binds to the central domain of p53 required for site-specific DNA binding thus inhibiting the ability of p53 to bind DNA. TP53BP1 also functions as a checkpoint protein with properties of a DNA double-strand break sensor. It is a putative substrate of ATM kinase and is phosphorylated in response to DNA damage and localizes to sites of double-strand breaks. Q12888 NM_005657 NP_005648.1

TP53BP1 Antibody, 53BP1 Antibody, p202 Antibody, p53-binding protein 1 Antibody, p53-binding protein 53bp1 Antibody, p53BP1 Antibody


Specifications

Target
Human TP53BP1 / 53BP1
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot
Immunogen
TP53BP1 / 53BP1 antibody was raised against synthetic phosphopeptide corresponding to residues surrounding Ser25/29 of human 53BP1.
Epitope
Ser25/Ser29
Specificity
Recognizes endogenous levels of 53BP1 only when phosphorylated at serine 25/29. Species cross-reactivity: Monkey.
Usage
Suitable for use in Western Blot.
Presentation
10 mM sodium HEPES, pH 7.5, 150 mM sodium chloride, 0.1 mg/ml BSA, < 0.02% sodium azide, 50% glycerol
Storage
May be stored at 4°C for short-term only. For long-term storage and to avoid freeze-thaw cycles, aliquot and store at -20°C. Aliquots are stable for at least 1 year at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/25/2018

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