Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 1D8] (IgG1) to Human TH / Tyrosine Hydroxylase
IHC - Paraffin, Immunofluorescence, Western blot
Rabbit Polyclonal (IgG) to Rat TH / Tyrosine Hydroxylase
IHC - Frozen
Rat TH / Tyrosine Hydroxylase
Rat (tested or 100% immunogen sequence identity)
IHC - Frozen (1:200 - 1:2000)
Specificity and Use
TH / Tyrosine Hydroxylase antibody was raised against tyrosine hydroxylase: Asp-Cys-Leu-Arg-Asn-Tyr-Ala-Ser-Arg-Ile-Gln-Arg-Pro-Phe-Ser-Val-Lys-Phe-Asp-Pro-Tyr.
The antibody blocks with tyrosine hydroxylase. Cells and fibres are found throughout the substantia nigra and ventral tegmental area in rat brain of 4% FA perfused tissue. Species cross-reactivity: Rat. NOT TESTED ON HUMAN.
Tyrosine hydroxylase in involved in the conversion of phenylalanine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines and as such has a key role in the physiology of adrenergic neurons. TH is encoded by four distinct mRNAs produced by alternative splicing of a single primary transcript. Expression of the mRNAs varies in different parts of the nervous system. Defects in TH are the cause of autosomal recessive Segawa syndrome.