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Anti-PVRL4 / Nectin 4 Antibody (aa27-351) LS-C150011

Catalog	Size	Price
LS-C150011-100	100 µg	Unavailable

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Anti-PVRL4 / Nectin 4 Antibody (aa27-351) LS-C37483

Antibody:	Mouse Monoclonal (IgG) to Human PVRL4 / Nectin 4
Reactivity:	Human
Application:	Western blot, Flow Cytometry, ELISA
Format:	Unconjugated

Anti-PVRL4 / Nectin 4 Antibody LS-C37484

Antibody:	Rat Monoclonal (IgG2a) to Mouse PVRL4 / Nectin 4
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Anti-PVRL4 / Nectin 4 Antibody (aa312-361) LS-C120225

Antibody:	Rabbit Polyclonal (IgG) to Human PVRL4 / Nectin 4
Reactivity:	Human
Application:	Western blot, ELISA
Format:	Unconjugated

Anti-PVRL4 / Nectin 4 Antibody LS-C401886

Antibody:	Rabbit Polyclonal (IgG) to Human PVRL4 / Nectin 4
Reactivity:	Human, Mouse
Application:	IHC, Western blot, ELISA
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Anti-PVRL4 / Nectin 4 Antibody (aa31-317, FITC) LS-C422595

Antibody:	Rabbit Polyclonal (IgG) to Human PVRL4 / Nectin 4
Reactivity:	Human
Application:	ICC, Western blot, ELISA
Format:	FITC Conjugated

Antibody:	Goat Polyclonal (IgG) to Human PVRL4 / Nectin 4
Reactivity:	Human
Application:	IHC - Paraffin, Western blot, Flow Cytometry
Format:	Unconjugated

Details

Target:	Human PVRL4 / Nectin 4
Host:	Goat
Reactivity:	Human (tested or 100% immunogen sequence identity)
Clonality:	IgG Polyclonal
Conjugations:	Unconjugated
Purification:	Immunoaffinity purified
Modifications:	Unmodified

Applications

Approved:

IHC - Paraffin (5 - 15 µg/ml)
Western blot (0.1 µg/ml)
Flow Cytometry

Specificity and Use

Immunogen:	PVRL4 / Nectin 4 antibody was raised against mouse myeloma cell line NS0-derived recombinant human Nectin4 Gly27-Val351 Accession # Q96NY8.
Epitope:	aa27-351
Specificity:	Detects human Nectin4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 75% cross-reactivity with.
Usage:	Western Blot, 0.1 µg/ml, Recombinant Human Nectin-4. Flow Cytometry, 2.5 µg/106 cells, MCF-7 human breast cancer cell line. Immunohistochemistry, 5-15 µg/ml.

Packaging

Presentation:	Lyophilized from 0.2 um filtered solution in PBS, trehalose
Reconstitution:	Sterile PBS. Resuspend to 500 ul
Storage:	Store lyophilized at 4°C. Once reconstituted, aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions:	For research use only.

About PVRL4 / Nectin 4

Uniprot: Q96NY8 NCBI: NM_030916 NP_112178.2

Synonyms: PVRL4 Antibody, EDSS1 Antibody, Nectin 4 Antibody, Ig superfamily receptor LNIR Antibody, Poliovirus receptor-like 4 Antibody, LNIR Antibody, Nectin-4 Antibody, Poliovirus receptor-related 4 Antibody

Description: PVRL4 / Nectin 4 is a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients.

(More About PVRL4 / Nectin 4)

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Immunohistochemistry

Nectin-4 in Human Placenta. Nectin-4 was detected in immersion fixed paraffin-embedded sections of human placenta using 10 ug/ml Goat Anti-Human Nectin-4 Antigen Affinity-purified Polyclonal Antibody overnight at 4°C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic. Tissue was stained with Anti-Goat HRP-DAB (brown) and counterstained with hematoxylin (blue).

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Date Requested: 6/24/2017

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