Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
NEIL1 antibody was raised against synthetic peptide located between aa270-319 of human NEIL1 (Q96FI4, NP_078884). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Monkey (100%); Orangutan (92%); Galago (85%).
LS-E23281 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C151557. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Lyophilized from PBS with 2% sucrose
Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year); Short term (less than one week): +4°C. Avoid repeat freeze-thaw cycles.
NEIL1 Antibody, DNA glycosylase/AP lyase Neil1 Antibody, Endonuclease VIII Antibody, Endonuclease 8-like 1 Antibody, Endonuclease VIII-like 1 Antibody, FPG1 Antibody, HFPG1 Antibody, Nei homolog 1 Antibody, NEI1 Antibody, Nei-like protein 1 Antibody, NEH1 Antibody
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand.