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Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
Gene Name: | O-6-methylguanine-DNA methyltransferase |
Synonyms: | MGMT |
Target Sequences: | NM_002412 NP_002403.2 P16455 |
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