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Anti-MCL1 / MCL 1 Antibody LS-C41333

Ordering

Wt. Vol. Conc. Price
- 50 µl - $205
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular MCL1 / MCL 1 Antibodies

Anti-MCL1 / MCL 1 Antibody (FITC) LS-C262847
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Human, Mouse
IHC, Western blot, Flow Cytometry, ELISA
FITC Conjugated
Anti-MCL1 / MCL 1 Antibody (clone 2E11) IHC-plus™ LS-B10210
Mouse Monoclonal [clone 2E11] (IgG2a) to Human MCL1 / MCL 1
Human
IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (5)
Rabbit Polyclonal (IgG) to Mouse MCL1 / MCL 1
Mouse
Western blot
Unconjugated

Details

Mouse MCL1 / MCL 1
Rabbit
Mouse (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

Western blot

Specificity and Use

MCL1 / MCL 1 antibody was raised against recombinant mouse MCL1.
Recombinant (partial)

Packaging

Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.
Store at -20°C. Aliquot to avoid freeze/thaw cycles. Store undiluted.
For research use only.

Publications (5)

1
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Molecular and cellular biology. 2007 27:4328-39. [PubMed:17371841] [PMC:PMC1900055]
2
The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation. Peperzak V, Veraar EA, Keller AM, Xiao Y, Borst J. Journal of immunology (Baltimore, Md. : 1950). 2010 185:6670-8. [PubMed:21048108]
3
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. The Journal of biological chemistry. 2011 286:5921-33. [PubMed:21159778] [PMC:PMC3037705]
4
Hepatitis B virus X protein enhances cisplatin-induced hepatotoxicity via a mechanism involving degradation of Mcl-1. Hu L, Chen L, Li L, Sun H, Yang G, Chang Y, Tu Q, Wu M, Wang H. Journal of virology. 2011 85:3214-28. [PubMed:21228225] [PMC:PMC3067872]
5
A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination. Baumgartner CK, Yagita H, Malherbe LP. Journal of immunology (Baltimore, Md. : 1950). 2012 189:2309-17. [PubMed:22844120] [PMC:PMC3424363]
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About MCL1 / MCL 1

Q07820 NM_021960 NP_068779.1

MCL1 Antibody, BCL2L3 Antibody, Bcl-2-like protein 3 Antibody, Bcl-2-related protein EAT/mcl1 Antibody, Bcl2-L-3 Antibody, MCL1S Antibody, MCL1L Antibody, Myeloid cell leukemia ES Antibody, MCL 1 Antibody, MCL1-ES Antibody, TM Antibody, EAT Antibody, Mcl-1 Antibody

Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types.

Western blot

Western blot
A20 cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit anti-Mcl-1 polyclonal antibody. Proteins were visualized using donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection
 

Requested From: United States
Date Requested: 12/11/2016

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