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Anti-Leptin Antibody (Biotin) LS-C187760

Catalog Size Price
LS-C187760-50 50 µg (0.1 mg/ml) Unavailable

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100% Guaranteed
Rabbit Polyclonal (IgG) to Human Leptin
Human
Western blot, ELISA
Biotin Conjugated

Details

Human Leptin
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Biotin
Affinity purified
Unmodified

Applications

  • Western blot (0.1 - 0.2 µg/ml)
  • ELISA (0.25 - 1 µg/ml)

Specificity and Use

Leptin antibody was raised against (PHP198).
This product recognizes human leptin, a 16KDa major adipose-derived hormone and member of the leptin family, which plays a key role in appetite control and the regulation of energy expenditure. Secreted leptin associates with proteins within the bloodstream and is transported to the brain, where it inhibits or up-regulates the activity of neuropeptides such as neuropeptide Y (NPY) and alpha-melanocyte-stimulating hormone respectively. Leptin is a recognized marker of obesity, with a correlation between circulating levels of leptin and body fat mass, and defects in leptin production result in severe obesity. Regulators of leptin expression include insulin, cortisol, cAMP and thiazolidinediones.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

PBS
500 µl Sterile PBS
Prior to reconstitution, +4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About Leptin

P41159 NM_000230 NP_000221.1

LEP Antibody, Leptin Antibody, LEPD Antibody, Obese protein Antibody, Obese, mouse, homolog of Antibody, Obesity factor Antibody, OBS Antibody, OB Antibody

Leptin is a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing.

Requested From: 
Date Requested: 8/19/2017

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