Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse, Rat, Hamster, Pig (at least 90% immunogen sequence identity)
Western blot (1 - 3 µg/ml)
Specificity and Use
KPI-2 / LMTK2 antibody was raised against synthetic peptide RCINSESSTD from an internal region of human LMTK2 (NP_055731.2). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Elephant, Panda, Dog, Horse, Rabbit (100%); Mouse, Rat, Hamster, Pig (90%); Bat (80%).
LS-E27465 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C139640. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Peptide ELISA: antibody detection limit dilution 1:1000. Western blot: Approx 150kD band observed in Human Brain (Cerebellum) lysates (calculated MW of 165kD according to NP_055731.2). Recommended concentration: 1-3 ug/ml.
KPI-2 / LMTK2 belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex.