Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
KPI-2 / LMTK2 belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.
|Gene Name:||lemur tyrosine kinase 2|
|Family/Subfamily:||Protein Kinase , LMR|
|Synonyms:||LMTK2, AATYK2, Brain-enriched kinase, Cprk, Kinase phosphatase inhibitor 2, Kinase/phosphatase/inhibitor 2, KPI2, LMR2, HBREK, BREK, CDK5/p35-regulated kinase, KIAA1079, KPI-2, Lemur tyrosine kinase 2|
|Target Sequences:||NM_014916 NP_055731.2 Q8IWU2|
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