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KPI-2 / LMTK2
lemur tyrosine kinase 2
KPI-2 / LMTK2 belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.
| Gene Name: | lemur tyrosine kinase 2 |
| Family/Subfamily: | Protein Kinase , LMR |
| Synonyms: | LMTK2, AATYK2, Brain-enriched kinase, Cprk, Kinase phosphatase inhibitor 2, Kinase/phosphatase/inhibitor 2, KPI2, LMR2, HBREK, BREK, CDK5/p35-regulated kinase, KIAA1079, KPI-2, Lemur tyrosine kinase 2 |
| Target Sequences: | NM_014916 NP_055731.2 Q8IWU2 |
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