Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Protein G purified
IHC - Frozen, Immunofluorescence, Flow Cytometry
Specificity and Use
Recognizes a 140kD glycoprotein which is the a subunit of the CD41/CD61 (GPIIb/IIIa, aIIbb3) complex called glycoprotein IIb (GPIIb).
Suitable for use in indirect immunofluorescence staining of human cells for flow cytometric analysis using 1 ug/1E6 cells and is tested for immunohistochemical staining of acetone-fixed frozen sections.
PBS, pH 7.2, 0.1% sodium azide.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen.