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Anti-HTRA1 Antibody (aa381-412) LS-C98879

Ordering

Wt. Vol. Conc. Price
- 400 µl - $305
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular HTRA1 Antibodies

Anti-HTRA1 Antibody (N-Terminus, Biotin) LS-C278267
Rabbit Polyclonal (IgG) to Human HTRA1
Human, Mouse
IHC, Immunofluorescence, Western blot, ELISA
Biotin Conjugated
Anti-HTRA1 Antibody (aa204-364, Biotin) LS-C297382
Rabbit Polyclonal (IgG) to Human HTRA1
Human
Western blot, ELISA
Biotin Conjugated
Western blot Image

100% Guaranteed 100% Guaranteed Publications Publications (1)
Rabbit Polyclonal to Human HTRA1
Human
IHC - Paraffin, Western blot
Unconjugated

Details

Human HTRA1
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Ammonium sulfate precipitation
Unmodified

Applications

  • IHC - Paraffin (1:50 - 1:100)
  • Western blot (1:1000)

  • IHC - Paraffin

Specificity and Use

HTRA1 antibody was raised against kLH-conjugated synthetic peptide between amino acids 381-412 from C-terminal region of human HtrA1.
LS-E2355 - Lyophilized - 100 µg - $145.00
aa381-412

Packaging

PBS, 0.09% sodium azide
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
For research use only.

Publications (1)

1
Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. Chamberland A, Wang E, Jones AR, Collins-Racie LA, LaVallie ER, Huang Y, Liu L, Morris EA, Flannery CR, Yang Z. The Journal of biological chemistry. 2009 284:27352-9. [PubMed:19657146] [PMC:PMC2785663]

About HTRA1

Q92743 NM_002775 NP_002766.1

HTRA1 Antibody, ARMD7 Antibody, HtrA serine peptidase 1 Antibody, IGFBP5-protease Antibody, HtrA Antibody, ORF480 Antibody, Serine protease 11 Antibody, CARASIL Antibody, L56 Antibody, PRSS11 Antibody, Serine protease HTRA1 Antibody

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space.

Immunohistochemistry

Immunohistochemistry
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Western blot

Western blot
HtrA1-K396 western blot of HeLa cell line lysates (35 ug/lane). The HtrA1 antibody detected the HtrA1 protein (arrow).

Requested From: United States
Date Requested: 12/8/2016

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