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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HTRA1

HtrA serine peptidase 1

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Gene Name: HtrA serine peptidase 1
Family/Subfamily: Protease , Serine S1C
Synonyms: HTRA1, ARMD7, HtrA serine peptidase 1, IGFBP5-protease, HtrA, ORF480, Serine protease 11, CARASIL, L56, PRSS11, Serine protease HTRA1
Target Sequences: NM_002775 NP_002766.1 Q92743

Publications (1)

1
Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. Chamberland A, Wang E, Jones AR, Collins-Racie LA, LaVallie ER, Huang Y, Liu L, Morris EA, Flannery CR, Yang Z. The Journal of biological chemistry. 2009 284:27352-9. [PubMed:19657146] [PMC:PMC2785663] Related Antibodies: LS-C98879.

Filtered By: None
Target
HTRA1 (53)
Reactivity
Human (52)
Mouse (11)
Rat (2)
Bovine (5)
Chimpanzee (3)
Dog (1)
E. coli (16)
Gibbon (3)
Monkey (4)
Pig (4)
Application
IHC (27)
IHC-P (3)
WB (53)
ELISA (13)
ICC (3)
IF (11)
IP (1)
Host
rabbit (53)
Isotype
IgG (45)
Clonality
polyclonal pc (53)
Format
AP Conjugated (2)
APC (3)
APC Conjugated (5)
Azide-free (2)
Biotin Conjugated (7)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (8)
HRP Conjugated (6)
PE Conjugated (5)
Unconjugated (14)
Epitope
aa10-146 (10)
aa204-364 (9)
aa116-147 (8)
aa304-442 (8)
aa381-412 (8)
aa122-171 (4)
aa234-249 (2)
Publications
No (52)
Yes (1)
Showing 1-25 of 53 results

HTRA1 Antibody (aa381-412) LS-C98879
Publications (1)
Publications (1)
Rabbit Polyclonal to Human HTRA1
Human
IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
HtrA1-K396 western blot of HeLa cell line lysates (35 ug/lane). The HtrA1 antibody detected the HtrA1 protein (arrow).
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
HtrA1-K396 western blot of HeLa cell line lysates (35 ug/lane). The HtrA1 antibody detected the HtrA1 protein (arrow).

HTRA1 Antibody (aa116-147) LS-C327589
Rabbit Polyclonal (IgG) to Human HTRA1
Mouse, Human
IF IHC WB
Unconjugated
200µl 0.25mg/ml  $530.00

HTRA1 Antibody (aa116-147, Biotin) LS-C278267
Rabbit Polyclonal (IgG) to Human HTRA1
Mouse, Human
ELISA IF IHC WB
Biotin Conjugated
200µl 0.5mg/ml  $635.00

HTRA1 Antibody (aa116-147, FITC) LS-C278268
Rabbit Polyclonal (IgG) to Human HTRA1
Mouse, Human
ELISA IF IHC WB
FITC Conjugated
200µl  $680.00

HTRA1 Antibody (aa116-147, Azide-free, HRP) LS-C278269
Rabbit Polyclonal (IgG) to Human HTRA1
Mouse, Human
ELISA IF IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

HTRA1 Antibody (aa116-147, AP) LS-C278265
Rabbit Polyclonal (IgG) to Human HTRA1
Mouse, Human
ELISA IF IHC WB
AP Conjugated
200µl  $680.00

HTRA1 Antibody (aa116-147, APC) LS-C278266
Rabbit Polyclonal (IgG) to Human HTRA1
Mouse, Human
ELISA IF IHC WB
APC Conjugated
200µl  $680.00

HTRA1 Antibody (aa116-147, PE) LS-C278270
Rabbit Polyclonal (IgG) to Human HTRA1
Mouse, Human
ELISA IF IHC WB
PE Conjugated
200µl  $680.00

HTRA1 Antibody (aa204-364) LS-C294536
Rabbit Polyclonal (IgG) to Human HTRA1
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00; 10ml 0.5mg/ml  $2,310.00
Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HTRA1 Antibody (aa204-364, HRP) LS-C714468
Rabbit Polyclonal (IgG) to Human HTRA1
Human
IHC WB
HRP Conjugated
20µl  $225.00; 100µl  $305.00; 200µl  $365.00; 1ml  $755.00; 10ml  $3,000.00
Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HTRA1 Antibody (aa204-364, Biotin) LS-C297382
Rabbit Polyclonal (IgG) to Human HTRA1
Human
IHC WB
Biotin Conjugated
100µl 0.5mg/ml  $455.00
Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HTRA1 Antibody (aa204-364, FITC) LS-C696497
Rabbit Polyclonal (IgG) to Human HTRA1
Human
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $695.00; 10ml  $2,775.00
Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HTRA1 Antibody (aa204-364, Cy3) LS-C705455
Rabbit Polyclonal (IgG) to Human HTRA1
Human
IHC WB
Cy3 Conjugated
20µl  $255.00; 100µl  $375.00; 200µl  $465.00; 1ml  $1,155.00; 10ml  $4,620.00
Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HTRA1 Antibody (aa116-147) LS-C98878
Rabbit Polyclonal to Human HTRA1
Mouse, Human
IF IHC IHC-P WB
Unconjugated
400µl  $305.00
HtrA1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Confocal immunofluorescence of HtrA1 Antibody with HeLa cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
HtrA1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Confocal immunofluorescence of HtrA1 Antibody with HeLa cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

HTRA1 Antibody LS-C666265
Rabbit Polyclonal (IgG) to Human HTRA1
Human
ELISA IF IHC IP WB
Unconjugated
100µg  $335.00

HTRA1 Antibody (aa234-249) LS-C190914
Rabbit Polyclonal (IgG) to Human HTRA1
Mouse, Dog, Bovine, Rat, Human
ICC IF WB
Unconjugated
100µg  $465.00

HTRA1 Antibody LS-C332688
Rabbit Polyclonal (IgG) to Human HTRA1
Mouse, Human
IF IHC WB
Unconjugated
50µl  $305.00
Western blot analysis of extracts of Mouse brain cells.
Western blot analysis of extracts of Mouse brain cells.

HTRA1 Antibody (aa381-412) LS-C327588
Rabbit Polyclonal (IgG) to Human HTRA1
Human
IHC WB
Unconjugated
200µl 0.25mg/ml  $530.00

HTRA1 Antibody (aa381-412, Biotin) LS-C278273
Rabbit Polyclonal (IgG) to Human HTRA1
Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

HTRA1 Antibody (aa381-412, FITC) LS-C278274
Rabbit Polyclonal (IgG) to Human HTRA1
Human
ELISA IHC WB
FITC Conjugated
200µl  $680.00

HTRA1 Antibody (aa381-412, Azide-free, HRP) LS-C278275
Rabbit Polyclonal (IgG) to Human HTRA1
Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

HTRA1 Antibody (aa381-412, PE) LS-C278276
Rabbit Polyclonal (IgG) to Human HTRA1
Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

HTRA1 Antibody (aa381-412, APC) LS-C278271
Rabbit Polyclonal (IgG) to Human HTRA1
Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

HTRA1 Antibody (aa381-412, AP) LS-C278272
Rabbit Polyclonal (IgG) to Human HTRA1
Human
ELISA IHC WB
AP Conjugated
200µl  $680.00

HTRA1 Antibody LS-C662735
Rabbit Polyclonal to Human HTRA1
Human
IHC IHC-P WB
Unconjugated
100µg  $355.00
Immunohistochemistry - Anti-HTRA1/Htra Picoband antibody
Western blot - Anti-HTRA1/Htra Picoband antibody
Immunohistochemistry - Anti-HTRA1/Htra Picoband antibody
Western blot - Anti-HTRA1/Htra Picoband antibody
Showing 1-25 of 53 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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