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HTRA1

HtrA serine peptidase 1

Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.

Gene Name: HtrA serine peptidase 1
Family/Subfamily: Protease , Serine S1C
Synonyms: HTRA1, ARMD7, HtrA serine peptidase 1, IGFBP5-protease, HtrA, ORF480, Serine protease 11, CARASIL, L56, PRSS11, Serine protease HTRA1
Target Sequences: NM_002775 NP_002766.1 Q92743

Publications (2)

1
Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. Chamberland A, Wang E, Jones AR, Collins-Racie LA, LaVallie ER, Huang Y, Liu L, Morris EA, Flannery CR, Yang Z. The Journal of biological chemistry. 2009 284:27352-9. [PubMed:19657146] [PMC:PMC2785663] Related Antibodies: LS-C98879.
2
The Serine Protease HTRA-1 Is a Biomarker for ROP and Mediates Retinal Neovascularization. Leah A Owen, Kinsey Shirer, Samuel A Collazo, Kathryn Szczotka, Shawna Baker, Blair Wood, Lara Carroll, Benjamin Haaland, Takeshi Iwata, Lakshmi D Katikaneni, Margaret M DeAngelis. Frontiers in molecular neuroscience. 2020 December;13:605918. [Full Text Article] [PubMed:33281553] [PMC:PMC7705345]

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Products
Antibodies (50)
Primary (50)
HTRA1 (50)
Human (49)
Mouse (13)
Rat (6)
Bovine (4)
Chimpanzee (3)
Dog (1)
E. coli (16)
Gibbon (3)
Monkey (3)
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IHC (16)
IHC-P (4)
WB (50)
ELISA (12)
ICC (1)
IF (8)
Peptide-ELISA (1)
rabbit (50)
IgG (17)
polyclonal pc (50)
APC (3)
APC Conjugated (5)
Azide-free (2)
Biotin Conjugated (6)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (5)
Unconjugated (16)
aa10-146 (8)
aa204-364 (8)
aa304-442 (8)
aa116-147 (7)
aa381-412 (7)
aa122-171 (4)
aa234-249 (2)
No (49)
Yes (1)
HTRA1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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HTRA1 Rabbit anti-Human Polyclonal (aa381-412) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
HTRA1 Antibody - HtrA1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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HTRA1 Rabbit anti-Human Polyclonal (aa116-147) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
200 µl/$393
HTRA1 Antibody - HTRA1 antibody Western blot of Fetal Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HTRA1 Rabbit anti-Human Polyclonal (aa122-171) Antibody
Human
WB
Unconjugated
100 µl/$424
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HTRA1 Rabbit anti-Human Polyclonal (aa234-249) Antibody
Mouse, Dog, Bovine, Rat, Human
ICC, IF, WB
Unconjugated
100 µl/$634
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HTRA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
HTRA1 Antibody - Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HTRA1 Rabbit anti-Human Polyclonal (aa204-364) Antibody
Human
WB
Unconjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$597; 2 ml/$826; 5 ml/$1,352
HTRA1 Antibody - Western blot of recombinant HTRA1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HTRA1 Rabbit anti-Human Polyclonal (aa204-364) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$329; 200 µl/$381; 500 µl/$550; 1 ml/$654; 2 ml/$890; 5 ml/$1,487
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HTRA1 Rabbit anti-Human Polyclonal (aa116-147) Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
200 µl/$734
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HTRA1 Rabbit anti-Human Polyclonal (aa116-147) (Biotin) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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HTRA1 Rabbit anti-Human Polyclonal (aa116-147) (FITC) Antibody
Mouse, Human
ELISA, IF, IHC, WB
FITC Conjugated
200 µl/$952
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HTRA1 Rabbit anti-Human Polyclonal (aa116-147) (APC) Antibody
Mouse, Human
ELISA, IF, IHC, WB
APC Conjugated
200 µl/$952
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HTRA1 Rabbit anti-Human Polyclonal (aa116-147) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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HTRA1 Rabbit anti-Human Polyclonal (aa116-147) (PE) Antibody
Mouse, Human
ELISA, IF, IHC, WB
PE Conjugated
200 µl/$952
HTRA1 Antibody - Immunohistochemistry of paraffin-embedded Human brain tissue  using HTRA1  Polyclonal Antibody at dilution of 1:55(×200)
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HTRA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HTRA1 Antibody - Immunohistochemistry - Anti-HTRA1/Htra Picoband antibody
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HTRA1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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HTRA1 Rabbit anti-Human Polyclonal (aa381-412) Antibody
Human
IHC, WB
Unconjugated
200 µl/$734
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HTRA1 Rabbit anti-Human Polyclonal (aa381-412) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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HTRA1 Rabbit anti-Human Polyclonal (aa381-412) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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HTRA1 Rabbit anti-Human Polyclonal (aa381-412) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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HTRA1 Rabbit anti-Human Polyclonal (aa381-412) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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HTRA1 Rabbit anti-Human Polyclonal (aa381-412) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
HTRA1 Antibody - Western blot analysis of extracts of HepG2 cells using HTRA1 antibody. The lane on the left was treated with blocking peptide.
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HTRA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
HTRA1 Antibody - IHC testing of FFPE human rectal cancer tissue with HTRA1 antibody at 1ug/ml. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.
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HTRA1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100 µg/$575
HTRA1 Antibody - Western blot analysis of HtrA1 in human A) HeLa cell lysate (1 minute exposure) and B) human 293 cell lysate (15 minute exposure) using antibody at 1:500.
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HTRA1 Rabbit anti-Human Polyclonal (aa234-249) Antibody
WB
Unconjugated
100 µl/$386
HTRA1 Antibody - Western blot of HTRA1 antibody.
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HTRA1 Rabbit anti-Human Polyclonal (aa10-146) Antibody
E. coli, Human
WB
Unconjugated
100 µl/$349; 200 µl/$408; 500 µl/$609; 1 ml/$762; 2 ml/$999; 5 ml/$1,729
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).