Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
HMG1 / HMGB1 antibody was raised against a synthetic peptide made to an internal portion of the human HMGB1 protein sequence (between residues 100-200). [UniProt #P09429]. Percent identity by BLAST analysis: Porcine (100%).
HMGB1 Antibody, Amphoterin Antibody, High mobility group protein B1 Antibody, High mobility group box 1 Antibody, High mobility group protein 1 Antibody, HMG1 Antibody, HMG3 Antibody, SBP-1 Antibody, High-mobility group box 1 Antibody, HMG-1 Antibody
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.
HMGB1 Antibody - Staining of HMGB1 in mouse liver. This image was taken for the unconjugated form of this product. Other forms have not been tested.
HMGB1 Antibody - Oligodendrocyte Marker - Detectionof HMGB1 (Green) in Hela cells. Nuclei (Blue) are counterstained with Hoecsht 33258. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of HMGB1 in whole cell HeLa lysate using LS-C2691. ECL exposure, 1 min. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of HMGB1 in whole cell HeLa lysate. ECL exposure, 1 min. This image was taken for the unconjugated form of this product. Other forms have not been tested.