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HMG1 / HMGB1

high mobility group box 1

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.

Gene Name: high mobility group box 1
Synonyms: HMGB1, Amphoterin, High mobility group protein B1, High mobility group box 1, High mobility group protein 1, HMG1, HMG3, SBP-1, High-mobility group box 1, HMG-1
Target Sequences: NM_002128 NP_002119.1 P09429

Publications (19)

1
Adenovirus membrane penetration activates the NLRP3 inflammasome. Barlan AU, Griffin TM, McGuire KA, Wiethoff CM. Journal of virology. 2011 85:146-55. (WB; Human) [PubMed:20980503] [PMC:PMC3014182]
2
Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice. Fazio EN, Dimattia GE, Chadi SA, Kernohan KD, Pin CL. BMC cell biology. 2011 12:17. (ICC, IHC; Mouse) [PubMed:21545732] [PMC:PMC3224136]
3
High-mobility group box 1 is essential for mitochondrial quality control. Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ, Lotze MT. Cell metabolism. 2011 13:701-11. (ICC, WB; Mouse) [PubMed:21641551] [PMC:PMC3293110]
4
SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA. Montie HL, Pestell RG, Merry DE. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:17425-36. [PubMed:22131404]
5
Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response. Wang W, Zhao F, Fang Y, Li X, Shen L, Cao T, Zhu H. Critical care (London, England). 2013 17:R44. (WB; Pig) [Full Text Article] [PubMed:23497622] [PMC:PMC3672474]
6
Cellular source and proinflammatory roles of high-mobility group box 1 in surgically injured rat vocal folds. Li-Jessen NYK, Powell M, Choi AJ, Lee BJ, Thibeault SL. The Laryngoscope. 2017 127:E193-E200. (WB; Human) [Full Text Article] [PubMed:27774594] [PMC:PMC5403630] Related Antibodies: LS-C2691.
7
Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap. Song W, Shen L, Wang Y, Liu Q, Goodwin TJ, Li J, Dorosheva O, Liu T, Liu R, Huang L. Nature communications. 2018 June;9:2237. [Full Text Article] [PubMed:29884866] [PMC:PMC5993831]
8
Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming. Frank MG, Fonken LK, Annis JL, Watkins LR, Maier SF. Brain, behavior, and immunity. 2018 March;69:62-73. [Full Text Article] [PubMed:29104062] [PMC:PMC5857401]
9
HMGB1 induction of clusterin creates a chemoresistant niche in human prostate tumor cells. Zhou J, Chen X, Gilvary DL, Tejera MM, Eksioglu EA, Wei S, Djeu JY. Scientific reports. 2015 October;5:15085. [Full Text Article] [PubMed:26469759] [PMC:PMC4606829]
10
Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros CJ, Ahadome SD, Shia DW, Chung K, Sandlin JM, Darmawan KF, Bhatt KV, Manze CC, Paul MK, Wilkinson DC, Yan W, Clark AT, Rickabaugh TM, Wallace WD, Graeber TG, Damoiseaux R, Gomperts BN. Cell reports. 2019 December;29:3488-3505.e9. [Full Text Article] [PubMed:31825831] [PMC:PMC6927560]
11
Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury. Claudia Espinosa-Garcia, Fahim Atif, Seema Yousuf, Iqbal Sayeed, Gretchen N Neigh, Donald G Stein. International journal of molecular sciences. 2020 May;21: [Full Text Article] [PubMed:32466385] [PMC:PMC7312827]
12
Serum vitamin D receptor and High Mobility Group Box-1 (HMGB1) levels in HIV-infected patients with different immunodeficiency status: A cross-sectional study. Indah Sapta Wardani, Mochammad Hatta, Risna Halim Mubin, Agussalim Bukhari, Mulyanto, Muhammad Nasrum Massi, Irawaty Djaharuddin, Burhanuddin Bahar, Aminuddin, Siti Wahyuni. Annals of medicine and surgery (2012). 2021 March;63:102174. [Full Text Article] [PubMed:33664952] [PMC:PMC7900012]
13
RAGE and HMGB1 Expression in Orbital Tissue Microenvironment in Graves' Ophthalmopathy. Dominika Lacheta, Krzysztof B Poslednik, Katarzyna Czerwaty, Nils Ludwig, Marta Molinska-Glura, Ireneusz Kantor, Anna Jablonska-Pawlak, Piotr Miskiewicz, Alicja Gluszko, Zygmunt Stopa, Jacek Brzost, Miroslaw J Szczepanski. Mediators of inflammation. 2021 March;2021:8891324. [Full Text Article] [PubMed:33776579] [PMC:PMC7979288] Related Antibodies: LS-C2691.
14
Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats. Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Derek N Wills, Dennis Otero, Cindy L Ehlers, Bruno Conti. Alcohol (Fayetteville, N.Y.). 2019 May;76:37-45. [Full Text Article] [PubMed:30554034] [PMC:PMC6336521]
15
Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures. Matthew G Frank, Jessica L Annis, Linda R Watkins, Steven F Maier. Brain, behavior, and immunity. 2019 August;80:678-687. [Full Text Article] [PubMed:31078691] [PMC:PMC6662571]
16
Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages. Ludovic Boytard, Tarik Hadi, Michele Silvestro, Hengdong Qu, Andrew Kumpfbeck, Rayan Sleiman, Kissinger Hyppolite Fils, Dornazsadat Alebrahim, Francesco Boccalatte, Matthias Kugler, Annanina Corsica, Bruce E Gelb, Glenn Jacobowitz, George Miller, Chiara Bellini, Jessica Oakes, Jean-Sébastien Silvestre, Lior Zangi, Bhama Ramkhelawon. Nature communications. 2020 August;11:4311. [Full Text Article] [PubMed:32855420] [PMC:PMC7453029]
17
Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior. Matthew G Frank, Laura K Fonken, Samuel D Dolzani, Jessica L Annis, Philip H Siebler, Dominic Schmidt, Linda R Watkins, Steven F Maier, Christopher A Lowry. Brain, behavior, and immunity. 2018 October;73:352-363. [Full Text Article] [PubMed:29807129] [PMC:PMC6129419]
18
Clinical Significance of High-Mobility Group Box 1 Protein (HMGB1) and Nod-Like Receptor Protein 3 (NLRP3) in Patients with Ulcerative Colitis. YanMin Chen, Dong Wu, LingJia Sun. Medical science monitor : international medical journal of experimental and clinical research. 2020 Jan;26:e919530. [Full Text Article] [PubMed:31901930] [PMC:PMC6977607]
19
Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma. Jianfeng Guo , Zhuo Yu , Dandan Sun, Yifang Zou, Yun Liu, Leaf Huang. Molecular cancer. 2021 Jan;20:10. [Full Text Article] [PubMed:33407548] [PMC:PMC7786897]
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HMG1 / HMGB1 Antibody - Anti-HMGB1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (1D5) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HMG1 / HMGB1 Antibody - Anti-HMGB1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (2F6) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HMG1 / HMGB1 Antibody - Anti-HMG1 / HMGB1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (IMG19N10B7) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$440
HMG1 / HMGB1 Antibody - HMGB1 Antibody - Staining of HMGB1 in mouse liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (aa100-200) Antibody
Mouse, Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
HMG1 / HMGB1 Antibody - HeLa cells grown in tissue culture and stained with HMG1 / HMGB1 antibody (red), chicken polyclonal antibody to Vimentin (green) and DNA (blue). The HMG1 / HMGB1 antibody antibody reveals strong nuclear staining which overlaps with the DNA stain.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (1F3) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$331
HMG1 / HMGB1 Antibody - Western blot of Acetyl-HMG-1 (K12) antibody
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$289; 100 µl/$319; 200 µl/$389
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (aa25-75) Antibody
Chicken, Mouse, Rat, Human, Monkey
WB
Unconjugated
100 µg/$386
HMG1 / HMGB1 Antibody - Anti-HMGB1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (1B11) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
HMG1 / HMGB1 Antibody - Immunohistochemistry of paraffin-embedded human gastric cancer using HMGB1 Antibody at dilution of 1:100
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
HMG1 / HMGB1 Antibody - Western blot of recombinant HMG1 / HMGB1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMG1 / HMGB1 Rabbit anti-Mouse Polyclonal (aa1-215) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535
HMG1 / HMGB1 Antibody - Western blot of recombinant HMG1 / HMGB1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMG1 / HMGB1 Rabbit anti-Mouse Polyclonal (aa1-215) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$311; 200 µl/$353; 500 µl/$496; 1 ml/$567
HMG1 / HMGB1 ELISA Kit
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Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
HMG1 / HMGB1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$752
HMG1 / HMGB1 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
13.72 - 10000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$917
HMG1 / HMGB1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Tissue Homogenates
1 Plate/$744
HMG1 / HMGB1 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$776
HMG1 / HMGB1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
HMG1 / HMGB1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
HMG1 / HMGB1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
HMG1 / HMGB1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
46.88 - 3000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$772
HMG1 / HMGB1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
HMG1 / HMGB1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$809
HMG1 / HMGB1 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
HMG1 / HMGB1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$746
HMG1 / HMGB1 Protein - Recombinant High Mobility Group Protein 1 By SDS-PAGE
Select
E. coli
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
26.4 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$3,201
Viewing 1-25 of 227 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).