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HMG1 / HMGB1

high mobility group box 1

DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.

Gene Name: high mobility group box 1
Synonyms: HMGB1, Amphoterin, High mobility group protein B1, High mobility group box 1, High mobility group protein 1, HMG1, HMG3, SBP-1, High-mobility group box 1, HMG-1
Target Sequences: NM_002128 NP_002119.1 P09429

Publications (18)

1
Adenovirus membrane penetration activates the NLRP3 inflammasome. Barlan AU, Griffin TM, McGuire KA, Wiethoff CM. Journal of virology. 2011 85:146-55. (WB; Human) [PubMed:20980503] [PMC:PMC3014182]
2
Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice. Fazio EN, Dimattia GE, Chadi SA, Kernohan KD, Pin CL. BMC cell biology. 2011 12:17. (ICC, IHC; Mouse) [PubMed:21545732] [PMC:PMC3224136]
3
High-mobility group box 1 is essential for mitochondrial quality control. Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ, Lotze MT. Cell metabolism. 2011 13:701-11. (ICC, WB; Mouse) [PubMed:21641551] [PMC:PMC3293110]
4
SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA. Montie HL, Pestell RG, Merry DE. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:17425-36. [PubMed:22131404]
5
Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response. Wang W, Zhao F, Fang Y, Li X, Shen L, Cao T, Zhu H. Critical care (London, England). 2013 17:R44. (WB; Pig) [Full Text Article] [PubMed:23497622] [PMC:PMC3672474]
6
Cellular source and proinflammatory roles of high-mobility group box 1 in surgically injured rat vocal folds. Li-Jessen NYK, Powell M, Choi AJ, Lee BJ, Thibeault SL. The Laryngoscope. 2017 127:E193-E200. (WB; Human) [Full Text Article] [PubMed:27774594] [PMC:PMC5403630] Related Antibodies: LS-C2691.
7
Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap. Song W, Shen L, Wang Y, Liu Q, Goodwin TJ, Li J, Dorosheva O, Liu T, Liu R, Huang L. Nature communications. 2018 June;9:2237. [Full Text Article] [PubMed:29884866] [PMC:PMC5993831]
8
Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming. Frank MG, Fonken LK, Annis JL, Watkins LR, Maier SF. Brain, behavior, and immunity. 2018 March;69:62-73. [Full Text Article] [PubMed:29104062] [PMC:PMC5857401]
9
HMGB1 induction of clusterin creates a chemoresistant niche in human prostate tumor cells. Zhou J, Chen X, Gilvary DL, Tejera MM, Eksioglu EA, Wei S, Djeu JY. Scientific reports. 2015 October;5:15085. [Full Text Article] [PubMed:26469759] [PMC:PMC4606829]
10
Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros CJ, Ahadome SD, Shia DW, Chung K, Sandlin JM, Darmawan KF, Bhatt KV, Manze CC, Paul MK, Wilkinson DC, Yan W, Clark AT, Rickabaugh TM, Wallace WD, Graeber TG, Damoiseaux R, Gomperts BN. Cell reports. 2019 December;29:3488-3505.e9. [Full Text Article] [PubMed:31825831] [PMC:PMC6927560]
11
Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury. Claudia Espinosa-Garcia, Fahim Atif, Seema Yousuf, Iqbal Sayeed, Gretchen N Neigh, Donald G Stein. International journal of molecular sciences. 2020 May;21: [Full Text Article] [PubMed:32466385] [PMC:PMC7312827]
12
Serum vitamin D receptor and High Mobility Group Box-1 (HMGB1) levels in HIV-infected patients with different immunodeficiency status: A cross-sectional study. Indah Sapta Wardani, Mochammad Hatta, Risna Halim Mubin, Agussalim Bukhari, Mulyanto, Muhammad Nasrum Massi, Irawaty Djaharuddin, Burhanuddin Bahar, Aminuddin, Siti Wahyuni. Annals of medicine and surgery (2012). 2021 March;63:102174. [Full Text Article] [PubMed:33664952] [PMC:PMC7900012]
13
RAGE and HMGB1 Expression in Orbital Tissue Microenvironment in Graves' Ophthalmopathy. Dominika Lacheta, Krzysztof B Poslednik, Katarzyna Czerwaty, Nils Ludwig, Marta Molinska-Glura, Ireneusz Kantor, Anna Jablonska-Pawlak, Piotr Miskiewicz, Alicja Gluszko, Zygmunt Stopa, Jacek Brzost, Miroslaw J Szczepanski. Mediators of inflammation. 2021 March;2021:8891324. [Full Text Article] [PubMed:33776579] [PMC:PMC7979288] Related Antibodies: LS-C2691.
14
Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats. Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Derek N Wills, Dennis Otero, Cindy L Ehlers, Bruno Conti. Alcohol (Fayetteville, N.Y.). 2019 May;76:37-45. [Full Text Article] [PubMed:30554034] [PMC:PMC6336521]
15
Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures. Matthew G Frank, Jessica L Annis, Linda R Watkins, Steven F Maier. Brain, behavior, and immunity. 2019 August;80:678-687. [Full Text Article] [PubMed:31078691] [PMC:PMC6662571]
16
Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages. Ludovic Boytard, Tarik Hadi, Michele Silvestro, Hengdong Qu, Andrew Kumpfbeck, Rayan Sleiman, Kissinger Hyppolite Fils, Dornazsadat Alebrahim, Francesco Boccalatte, Matthias Kugler, Annanina Corsica, Bruce E Gelb, Glenn Jacobowitz, George Miller, Chiara Bellini, Jessica Oakes, Jean-Sébastien Silvestre, Lior Zangi, Bhama Ramkhelawon. Nature communications. 2020 August;11:4311. [Full Text Article] [PubMed:32855420] [PMC:PMC7453029]
17
Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior. Matthew G Frank, Laura K Fonken, Samuel D Dolzani, Jessica L Annis, Philip H Siebler, Dominic Schmidt, Linda R Watkins, Steven F Maier, Christopher A Lowry. Brain, behavior, and immunity. 2018 October;73:352-363. [Full Text Article] [PubMed:29807129] [PMC:PMC6129419]
18
Clinical Significance of High-Mobility Group Box 1 Protein (HMGB1) and Nod-Like Receptor Protein 3 (NLRP3) in Patients with Ulcerative Colitis. YanMin Chen, Dong Wu, LingJia Sun. Medical science monitor : international medical journal of experimental and clinical research. 2020 Jan;26:e919530. [Full Text Article] [PubMed:31901930] [PMC:PMC6977607]
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HMG1 / HMGB1 (172)
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HMG1 / HMGB1 Antibody - Anti-HMGB1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (1D5) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$545
HMG1 / HMGB1 Antibody - Anti-HMGB1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (2F6) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$545
HMG1 / HMGB1 Antibody - Anti-HMG1 / HMGB1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (IMG19N10B7) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$515
HMG1 / HMGB1 Antibody - HMGB1 Antibody - Staining of HMGB1 in mouse liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (aa100-200) Antibody
Mouse, Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$376
HMG1 / HMGB1 Antibody - HMGB1 Antibody - Staining of HMGB1 in mouse liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Human
Flo, ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$406
HMG1 / HMGB1 Antibody - HeLa cells grown in tissue culture and stained with HMG1 / HMGB1 antibody (red), chicken polyclonal antibody to Vimentin (green) and DNA (blue). The HMG1 / HMGB1 antibody antibody reveals strong nuclear staining which overlaps with the DNA stain.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (1F3) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$321
HMG1 / HMGB1 Antibody - Western blot of Acetyl-HMG-1 (K12) antibody
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (aa25-75) Antibody
Chicken, Mouse, Rat, Human, Monkey
WB
Unconjugated
100 µg/$376
HMG1 / HMGB1 Antibody - Anti-HMGB1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (1B11) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$485
HMG1 / HMGB1 Antibody - Immunohistochemistry of paraffin-embedded human gastric cancer using HMGB1 Antibody at dilution of 1:100
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC
Unconjugated
50 µg/$284; 100 µg/$351
HMG1 / HMGB1 Antibody - Western blot of recombinant HMG1 / HMGB1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMG1 / HMGB1 Rabbit anti-Mouse Polyclonal (aa1-215) Antibody
Mouse, Human
ICC, IP, WB
Unconjugated
100 µl/$292; 200 µl/$331; 500 µl/$460; 1 ml/$525
HMG1 / HMGB1 Antibody - Western blot of recombinant HMG1 / HMGB1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMG1 / HMGB1 Rabbit anti-Mouse Polyclonal (aa1-215) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
200 µl/$343; 500 µl/$486; 1 ml/$557
HMG1 / HMGB1 Antibody - Anti-HMG1 / HMGB1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 20 ug/ml. This image was taken for the unmodified form of this product. Other forms have not been tested.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (Azide-free) (IMG19N10B7) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated, Azide-free
50 µg/$515
HMG1 / HMGB1 Antibody
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (4C9) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$419
HMG1 / HMGB1 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HMG1 / HMGB1 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$460
HMG1 / HMGB1 Antibody - Immunofluorescence of monoclonal antibody to HMGB1 on HeLa cell (antibody concentration 10 ug/ml).
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (1E6-E10) Antibody
Human
IF, WB
Unconjugated
100 µg/$407
HMG1 / HMGB1 Antibody - Anti-HMG1 / HMGB1 antibody IHC of human skin, epidermis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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HMG1 / HMGB1 Mouse anti-Human Monoclonal (IMG19N15F4) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$515
HMG1 / HMGB1 Antibody - Immunohistochemical analysis of HMGB1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$311
HMG1 / HMGB1 Antibody - Western blot of HMG-1 antibody
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (100-180 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
HMG1 / HMGB1 Antibody - Anti-HMGB1 antibody IHC of human, uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (aa131-180) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$505
HMG1 / HMGB1 Antibody - Western blot of HMG-1 antibody
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (N-Terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
HMG1 / HMGB1 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (aa121-170) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$485
HMG1 / HMGB1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (Acetyl-Lys12) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Pig, Human, Monkey
IHC-P, WB
Unconjugated
50 µl/$460
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal (aa9-36) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$614
HMG1 / HMGB1 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HMG1 / HMGB1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$555
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).