Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Specificity and Use
HLA-B antibody was raised against hLA Class 1 Antigen-B48, B60.
Recognizes the human HLA Class 1 Antigen-B48, B60. Additional cross-reactivity occurs with related proteins. Specificity was determined at a 1:10 dilution by the Microcytotoxicity Test under standard NIH conditions.
Suitable for use in Flow Cytometry, Cell Typing, Tissue Staining, and Chimerism Studies. Cytotoxicity: Add 0.9 ml of 1% BSA in PBS to 100 ul of10X working dilution.
100 µl deionized water
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C.
HLA-B Antibody, HLAB Antibody, MHC Class I HLA heavy chain Antibody, Leukocyte antigen class I-B Antibody, SPDA1 Antibody
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons.