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Anti-FTO Antibody (C-Terminus) LS-C187751

Ordering

Wt. Vol. Conc. Price
- 100 µl - $360
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular FTO Antibodies

Anti-FTO Antibody (N-Terminus) IHC-plus™ LS-B5891
Rabbit Polyclonal to Mouse FTO
Mouse, Human, Monkey, Rat, Bovine, Hamster, Horse, Pig, Sheep
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-FTO Antibody (aa400-505) IHC-plus™ LS-B7788
Rabbit Polyclonal to Human FTO
Human, Mouse, Primate
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human FTO
Human
Western blot, ELISA
Unconjugated

Details

Human FTO
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Antiserum
Unmodified

Applications

  • Western blot (1:500 - 1:1000)
  • ELISA

Specificity and Use

FTO antibody was raised against two peptides designed to the N- and C-terminal regions of the human FTO gene.
C-Terminus
Recognizes human FTO, otherwise known as fat mass and obesity-associated protein, a 60kD protein expressed ubiquitously with particularly high levels in the adrenal glands and brain. The gene was named FTO because a deletion in it resulted in fused toes and other abnormalities in mice. Since then, some correlation has been shown between carriers of the gene and obesity as well as an increased risk of Type 2 diabetes. The precise function of the gene is unknown but it shows homology with the enzyme AlkB, which oxidatively demethylates DNA. FTO gene expression has been shown to be highly upregulated in rats after food deprivation. A negative correlation with the expression of orexin peptide, which is involved in the stimulation of food intake, has also been found.

Packaging

Serum, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About FTO

Q9C0B1 Q9C0B1

FTO Antibody, KIAA1752 Antibody, Protein fto Antibody

Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes.

Requested From: United States
Date Requested: 12/5/2016

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