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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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DRD2 / Dopamine Receptor D2 Antibody (3rd Cytoplasmic Domain) LS‑C22921
Antibody
Dopamine Receptor D2 antibody LS-C22921 is an unconjugated rabbit polyclonal antibody to Dopamine Receptor D2 (DRD2) from rat and dog. Validated for ELISA and WB.
Catalog
Size
Price
LS-C22921-50
50 µg
Unavailable

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Product Description

Dopamine Receptor D2 antibody LS-C22921 is an unconjugated rabbit polyclonal antibody to Dopamine Receptor D2 (DRD2) from rat and dog. Validated for ELISA and WB.
About DRD2 / Dopamine Receptor D2
DRD2 / Dopamine Receptor D2 is the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. P14416 NM_000795 NP_000786.1

DRD2 Antibody, D2 dopamine receptor Antibody, D2R Antibody, Dopamine receptor D2 isoform Antibody, Dopamine 2 receptor Antibody, D(2) dopamine receptor Antibody, D2DR Antibody, Dopamine D2 receptor Antibody, Dopamine receptor D2 Antibody


Specifications

Target
Rat DRD2 / Dopamine Receptor D2
Host
Rabbit
Reactivity
Rat, Dog (tested or 100% immunogen sequence identity)
Predicted
Human, Bovine (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1 - 10 µg/ml)
  • ELISA (0.5 - 1 µg/ml)
Immunogen
A 27 amino acid peptide sequence from the rat D2 long form within the cytoplasmic loop #3. No significant homology with other receptors (D1, D2 short, and D3-D5).
Epitope
3rd Cytoplasmic Domain
Specificity
Recognizes rat Dopamine Receptor D2 long form. Recognizes canine D2R. Species sequence Homology: Human, bovine, and canine: 96%, Xenopus: 64%.
Usage
Suitable for use in Western Blot and ELISA. Western Blot: 1-10 ug/ml (Chemiluminescence technique). The predicted size of D2L form is approximately 50kD. However, additional bands at approximately 60 and 100kD, and others are typically seen in various tissues. Approximately 100-400 ug of membrane protein/lane should be loaded to visualize various bands. ELISA: 0.5-1.0 ug/ml (1 ug/ml immunogen peptide/well).
Presentation
100 mM Tris, pH 7.5, 0.2% BSA, 0.05% sodium azide, 40% glycerol.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/23/2018

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