Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 2AR1] (IgG1) to Human CXCR3
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [2AR1]
Protein G purified
Specificity and Use
CXCR3 antibody was raised against cXCR3 transfectants.
Recognizes recombinant, human CXCR3. Reacts specifically with CXCR3 transfectants. Does not recognizes the parental cell line using FACS analysis. Does not cross-react with CXCR1, CXCR2 and CXCR4 transfectants.
Suitable for use in Flow Cytometry. Flow Cytometry: 10 ul/10^5 cells to detect human CXCR3. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
HBS, pH 7.2, 0.54% BSA, 0.1% sodium azide.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration.