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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CHEK2 / CHK2 Antibody (Ser379) LS‑C176402
CHK2 antibody LS-C176402 is an unconjugated rabbit polyclonal antibody to CHK2 (CHEK2) from human, mouse and rat. Validated for IHC and WB.
Catalog
Size
Price
LS-C176402-100
100 µl
Unavailable

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Product Description

CHK2 antibody LS-C176402 is an unconjugated rabbit polyclonal antibody to CHK2 (CHEK2) from human, mouse and rat. Validated for IHC and WB.
About CHEK2 / CHK2
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. O96017 NM_007194 NP_009125.1

CHEK2 Antibody, BA444G7 Antibody, Cds1 homolog Antibody, Checkpoint kinase 2 Antibody, Checkpoint-like protein CHK2 Antibody, CHK2 checkpoint homolog Antibody, CHK2 Antibody, HCds1 Antibody, LFS2 Antibody, RAD53 Antibody, Rad53 homolog Antibody, HCHK2 Antibody, HuCds1 Antibody, PP1425 Antibody


Specifications

Target
Human CHEK2 / CHK2
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CHEK2 / CHK2 antibody was raised against synthetic peptide around Ser379 of human CHK2
Epitope
Ser379
Specificity
Human Chk2
Presentation
PBS, pH 7.2, 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

Western blot of Chk2 (S379) pAb in extracts from COS7 cells treated with UV 30'.
Western blot of Chk2 (S379) pAb in extracts from COS7 cells treated with UV 30'.

Western blot

Western blot of Chk2 (S379) pAb in extracts from COS7 cells treated with UV 30'.
Western blot of Chk2 (S379) pAb in extracts from COS7 cells treated with UV 30'.

Western blot

Western blot of Chk2 (S379) pAb in extracts from COS7 cells treated with UV 30'.
Western blot of Chk2 (S379) pAb in extracts from COS7 cells treated with UV 30'.

Western blot

Western blot of Chk2 (S379) pAb in extracts from COS7 cells treated with UV 30'.
Western blot of Chk2 (S379) pAb in extracts from COS7 cells treated with UV 30'.


Requested From: 
Date Requested: 6/19/2018

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