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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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CHEK2 / CHK2

checkpoint kinase 2

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells.

Gene Name: checkpoint kinase 2
Family/Subfamily: Protein Kinase , CDS1
Synonyms: CHEK2, BA444G7, Cds1 homolog, Checkpoint kinase 2, Checkpoint-like protein CHK2, CHK2 checkpoint homolog, CHK2, HCds1, LFS2, RAD53, Rad53 homolog, HCHK2, HuCds1, PP1425
Target Sequences: NM_007194 NP_009125.1 O96017

Viewing 1-25 of 169 items
CHEK2 / CHK2 Antibody - Anti-CHEK2 / CHK2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
CHEK2 / CHK2 Antibody - Anti-CHEK2 / CHK2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
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Mouse Monoclonal [clone 4B7] (IgG2a,k) to Human CHEK2 / CHK2
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
CHEK2 / CHK2 Antibody - Anti-CHEK2 / CHK2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Mouse Monoclonal [clone 73C175.1.1] (IgG1) to Human CHEK2 / CHK2
Human
IHC, IHC-P, WB
Unconjugated
50µg   $425.00
CHEK2 / CHK2 Antibody - Anti-CHEK2 / CHK2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 1.5 ug/ml.
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Mouse Monoclonal [clone 3E10] (IgG2a,k) to Human CHEK2 / CHK2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $545.00
CHEK2 / CHK2 Antibody - Anti-CHEK2 / CHK2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
CHEK2 / CHK2 Antibody - Anti-CHEK2 / CHK2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2
Human
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
CHEK2 / CHK2 Antibody - IHC of p-Chk2 (T68) pAb in paraffin-embedded human breast carcinoma tissue.
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Rabbit Polyclonal to Human CHEK2 / CHK2
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
Select
Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Human, Monkey
IHC, WB
Unconjugated
50µg   $435.00
CHEK2 / CHK2 Antibody - Immunohistochemistry of paraffin-embedded human lung cancer tissue.
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Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
CHEK2 / CHK2 Antibody - Western blot of Chk2 phosphorylation expression in UV treated Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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Rabbit Polyclonal to Human CHEK2 / CHK2
Mouse, Rat, Human
IHC, WB
Unconjugated
50µg   50µl   1µg/µl   $255.00; 100µg   100µl   1µg/µl   $305.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded breast tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI5C4] (IgG1) to Human CHEK2 / CHK2
Dog, Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1.43mg/ml   $345.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded breast tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI5C4] (IgG1) to Human CHEK2 / CHK2
Dog, Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded liver tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI10G7] (IgG1) to Human CHEK2 / CHK2
Dog, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl   0.66mg/ml   $345.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded liver tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI10G7] (IgG1) to Human CHEK2 / CHK2
Dog, Human, Monkey
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
CHEK2 / CHK2 Antibody - 1:100 staining rat liver tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
CHEK2 / CHK2 Antibody - 1:100 staining human TB tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
CHEK2 / CHK2 Antibody - 1:100 staining rat colon tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded liver tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI8D11] (IgG1) to Human CHEK2 / CHK2
Dog, Human, Monkey
Flo, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded colon tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI4C10] (IgG2b) to Human CHEK2 / CHK2
Dog, Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
100µl   1.88mg/ml   $345.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded colon tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI4C10] (IgG2b) to Human CHEK2 / CHK2
Dog, Human
Flo, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded colon tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2H5] (IgG2b) to Human CHEK2 / CHK2
Dog, Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
100µl   2.18mg/ml   $345.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded colon tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2H5] (IgG2b) to Human CHEK2 / CHK2
Dog, Human
Flo, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded colon tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI5C7] (IgG1) to Human CHEK2 / CHK2
Dog, Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
100µl   0.98mg/ml   $345.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded colon tissue using anti-CHEK2 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI5C7] (IgG1) to Human CHEK2 / CHK2
Dog, Human
Flo, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
CHEK2 / CHK2 Antibody - IHC of paraffin-embedded human lung carcinoma (A), liver carcinoma (B), breast carcinoma (C) and kidney carcinoma (D), showing nuclear localization with DAB staining using CHK2 mouse monoclonal antibody.
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Mouse Monoclonal [clone 1C12B8] (IgG2b) to Human CHEK2 / CHK2
Human
ELISA, IF, IHC, WB
Unconjugated
100µl   $385.00

Viewing 1-25 of 169 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).